ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Do pre-procedural laboratory parameters predict drug-eluting stent restenosis? [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(5): 457-464 | DOI: 10.5543/tkda.2015.48275

Do pre-procedural laboratory parameters predict drug-eluting stent restenosis?

Aslı Tanındı, Berkay Ekici, Hasan Fehmi Töre
Ufuk University Faculty Of Medicine, Department Of Cardiology, Ankara, Turkey


OBJECTIVE
Drug-eluting stents (DES) have considerably reduced the rates of in-stent restenosis (ISR). Several studies reported pre-procedural C-reactive protein (CRP), neutrophil to lymphocyte (N/L) ratio, red cell distribution width (RDW), serum uric acid (UA), and mean platelet volume (MPV) as independent predictors of ISR using bare metal stents. This study investigates whether any laboratory parameter obtained before the coronary stenting procedure is associated with ISR using DES in stable coronary artery disease.

METHODS
Three hundred fifteen stents were retrospectively analysed in 285 patients who had undergone coronary stenting and a control coronary angiography within one year of stenting, between January 2012 and April 2014. Pre-procedural complete blood count, biochemistry, and CRP were recorded. Off-line quantitative coronary angiography analysis was performed.

RESULTS
Overall restenosis rate was 10.2%. When the stents were analysed with respect to the presence of ISR, the number of diabetics and smokers was higher in the ISR group. CRP levels were significantly higher in the ISR group, but there were no differences in N/L, monocytes, eosinophils, RDW, MPV, UA, and total bilirubin levels. In the univariate regression analysis, DM, CRP, stent length, stent diameter, pre-procedural diameter stenosis, pre-procedural minimal lumen diameter (MLD), post-procedural residual diameter stenosis, post-procedural reference vessel diameter, and postprocedural MLD were predictors of ISR. However, multivariate regression analysis identified only DM and post-procedural residual stenosis as independent predictors of ISR.

CONCLUSION
Pre-procedural blood parameters do not independently predict ISR in DES, which is mainly determined by the presence of diabetes and post-procedural residual stenosis.

Keywords: Drug eluting stent, in-stent restenosis, predictors

How to cite this article
Aslı Tanındı, Berkay Ekici, Hasan Fehmi Töre. Do pre-procedural laboratory parameters predict drug-eluting stent restenosis?. Turk Kardiyol Dern Ars. 2015; 43(5): 457-464

Corresponding Author: Aslı Tanındı, Türkiye
Manuscript Language: English


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