Assessment of Insulin Resistance by the Hyperinsulinemic Euglycemic Glucose Clamp Technique in Young Men With Coronary Artery Disease

Insulin resistance has an important role in the pathogenesis of metabolic disorders such as hyperinsulinemia, glucose intolcrance, obcsity, and dyslipidemia, all established risk factors for coronary artery disease (CAD). In a number of prospective studies, an independent relationship was noted between CAD and hyperinsulinemia and insulin resistance; and has been suggcsted that insulin resistance isa risk factor for CAD. In this study, insulin res istance was studied by the hyperinsulinemic euglysemic glucose c lamp technique in ı6 male patients w ith CAD (Group ı), diagnosed all by coronary angiography and in 16 male healthy controls (Group 2), younger than 35 years. In our study, "M" value was found as a 4.37± 1.1 mg/kg/min in Group 1, and 7 .9± 1.1 mg/kg/min in Group 2. Insulin resistance was found in 7 of 16 in Group 1. w hile Group 2 no insulin resistance w as found, (p<0.05). In the patient group triglyceride, total and LDLcholesterol, insulin and C-peptide levels were statistically higher than controls (p<0.05). W e found that young patients with newly diagnosed CAD, did show insulin resistance, in variance from other studies. As a result, insulin resistance is an important risk factor in premature CAD.