ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
C-Reactive Protein to Albumin Ratio Predicts In-hospital Mortality in Patients with Acute Heart Failure [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2023; 51(3): 174-181 | DOI: 10.5543/tkda.2022.27741

C-Reactive Protein to Albumin Ratio Predicts In-hospital Mortality in Patients with Acute Heart Failure

Mehmet Rasih Sonsöz, Nazime Karadamar, Hüseyin Çağlar Yılmaz, Zehra Eroğlu, Kadir Kasim Şahin, Yelda Özateş, Ahmet Güler, Ahmet İlker Tekkeşin
Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul, Türkiye


OBJECTIVE
Acute heart failure remains at high risk of mortality despite recent advances in the management and treatment of heart failure. Recently, C-reactive protein to albumin ratio has been shown to predict all-cause mortality in heart failure with reduced ejection fraction. The association between C-reactive protein to albumin ratio and in-hospital mortality in patients with acute heart failure regardless of the left ventricular ejection fraction remains unknown.


METHODS
In this retrospective, single-center cohort study, we included 374 hospitalized patients with acute decompensated heart failure. We calculated C-reactive protein to albumin ratio and evaluated the relationship between the values and in-hospital mortality.


RESULTS
During hospitalization duration of 10 [6-17] days, need for hemodialysis/ultrafiltration, acute ischemic hepatitis, coagulopathy, ventricular tachycardia, invasive mechanical ventilation, and shock were more prevalent in the high C-reactive protein to albumin ratio (≥0.78) group compared to low C-reactive protein to albumin ratio (<0.78) group. Mortality was higher in the high C-reactive protein to albumin ratio group in comparison to the low C-reactive protein to albumin ratio group (36.7% vs. 12%; P < 0.001). C-reactive protein to albumin ratio was independently and significantly associated with in-hospital mortality (hazard ratio = 1.69, 95% CI: 1.02-2.82; P = 0.042) by multivariate Cox proportional hazard analysis. In receiver operating characteristic analysis, C-reactive protein to albumin ratio was able to predict in-hospital mortality (area under the curve value for in-hospital mortality was 0.72; P < 0.001).


CONCLUSION
Admission C-reactive protein to albumin ratio was associated with increased all-cause mortality in hospitalized patients with acute decompensated heart failure.

Keywords: Acute heart failure, albumin, C-reactive protein, C-reactive protein to albumin ratio, mortality

How to cite this article
Mehmet Rasih Sonsöz, Nazime Karadamar, Hüseyin Çağlar Yılmaz, Zehra Eroğlu, Kadir Kasim Şahin, Yelda Özateş, Ahmet Güler, Ahmet İlker Tekkeşin. C-Reactive Protein to Albumin Ratio Predicts In-hospital Mortality in Patients with Acute Heart Failure. Turk Kardiyol Dern Ars. 2023; 51(3): 174-181

Corresponding Author: Mehmet Rasih Sonsöz, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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