Archives of the Turkish Society of Cardiology
Serum apolipoprotein E concentrations among Turks: information additive to genotype relative to dyslipidemia and metabolic syndrom [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2007; 35(8): 449-457

Serum apolipoprotein E concentrations among Turks: information additive to genotype relative to dyslipidemia and metabolic syndrom

Altan Onat1, Altan Onat2, Gülay Hergenç3, Erkan Ayhan4, Zekeriya Kaya5, Zekeriya Küçükdurmaz6, Serkan Bulur7, Günay Can2, Nihan Erginel Ünaltuna8
1Turkish Society Of Cardiology, Istanbul
2Cerrahpaşa Medical Faculty, Istanbul University, Istanbul
3Biology Department, Yıldız Technical University, Istanbul
4S. Ersek Center For Cardiovascular Surgery, Istanbul
5Cardiology Department, Kartal Koşuyolu Hospital, Istanbul
6Cardiology Department, Gaziantep University Medical Faculty, Gaziantep
7Cardiology Department, Düzce U. Medical Faculty, Düzce
8Department Of Genetics, Institute For Experimental Medical Research, Istanbul University, Istanbul


OBJECTIVES
We investigated the relationship of serum apolipoprotein E (apoE) levels with dyslipidemia and metabolic syndrome (MS) in the general population and their degree of independence of the apoE genotype.

STUDY DESIGN
This cross-sectional study included a random sample of Turkish adults whose serum apoE concentrations were measured. Metabolic syndrome was defined with the ATP-III criteria with modification for male abdominal obesity.

RESULTS
Of 454 participants (222 men, 232 women; mean age 54.1±9.6 years), the median serum apoE concentration was 3.93 mg/dl with an interquartile range of 1.75 to 5.82 mg/dl. Higher apoE concentrations were found in male carriers of the ε4 allele than homozygous ε3 subjects. Multivariate analysis showed the apoE genotype (grouped into 3) as a determinant of apoE levels, and serum apoB levels as a major covariate. In logistic regression analysis, doubling of the apoE level showed significant associations, independent of the apoE polymorphism, with total cholesterol, elevated apoB (OR 4.54, 95% CI 2.83; 12.3) and triglyceride/HDL-cholesterol dyslipidemia (OR 2.82, 95% CI 1.67; 5.18). Doubling of the apoE level was also associated in both genders with MS (OR 1.72, 95% CI 1.24; 2.38), after adjustment for confounders.

CONCLUSION
ApoE concentrations in Turkish adults are significantly linked to serum total cholesterol, hyperapoB, and atherogenic dyslipidemia, independent of the apoE polymorphism. They are also significantly and independently associated with MS. Male carriers of the ε4 allele have no lower apoE concentrations than homozygous ε3 individuals, suggesting a close link between apoE and apoB levels.

Keywords: Alleles, apolipoproteins B, apolipoproteins E; cholesterol, LDL; dyslipidemias; genotype; metabolic syndrome X

How to cite this article
Altan Onat, Altan Onat, Gülay Hergenç, Erkan Ayhan, Zekeriya Kaya, Zekeriya Küçükdurmaz, Serkan Bulur, Günay Can, Nihan Erginel Ünaltuna. Serum apolipoprotein E concentrations among Turks: information additive to genotype relative to dyslipidemia and metabolic syndrom. Turk Kardiyol Dern Ars. 2007; 35(8): 449-457

Corresponding Author: Altan Onat, Türkiye
© Copyright 2020 Archives of the Turkish Society of Cardiology
LookUs & Online Makale