Turk Kardiyol Dern Ars. 2007; 35(8): 449-457
Serum apolipoprotein E concentrations among Turks: information additive to genotype relative to dyslipidemia and metabolic syndrom
, Altan Onat2
, Gülay Hergenç3
, Erkan Ayhan4
, Zekeriya Kaya5
, Zekeriya Küçükdurmaz6
, Serkan Bulur7
, Günay Can2
, Nihan Erginel Ünaltuna81
Turkish Society Of Cardiology, Istanbul2
Cerrahpaşa Medical Faculty, Istanbul University, Istanbul3
Biology Department, Yıldız Technical University, Istanbul4
S. Ersek Center For Cardiovascular Surgery, Istanbul5
Cardiology Department, Kartal Koşuyolu Hospital, Istanbul6
Cardiology Department, Gaziantep University Medical Faculty, Gaziantep7
Cardiology Department, Düzce U. Medical Faculty, Düzce8
Department Of Genetics, Institute For Experimental Medical Research, Istanbul University, Istanbul
OBJECTIVES We investigated the relationship of serum apolipoprotein E (apoE) levels with dyslipidemia and metabolic syndrome (MS) in the general population and their degree of independence of the apoE genotype.
STUDY DESIGN This cross-sectional study included a random sample of Turkish adults whose serum apoE concentrations were measured. Metabolic syndrome was defined with the ATP-III criteria with modification for male abdominal obesity.
RESULTS Of 454 participants (222 men, 232 women; mean age 54.1±9.6 years), the median serum apoE concentration was 3.93 mg/dl with an interquartile range of 1.75 to 5.82 mg/dl. Higher apoE concentrations were found in male carriers of the ε4 allele than homozygous ε3 subjects. Multivariate analysis showed the apoE genotype (grouped into 3) as a determinant of apoE levels, and serum apoB levels as a major covariate. In logistic regression analysis, doubling of the apoE level showed significant associations, independent of the apoE polymorphism, with total cholesterol, elevated apoB (OR 4.54, 95% CI 2.83; 12.3) and triglyceride/HDL-cholesterol dyslipidemia (OR 2.82, 95% CI 1.67; 5.18). Doubling of the apoE level was also associated in both genders with MS (OR 1.72, 95% CI 1.24; 2.38), after adjustment for confounders.
CONCLUSION ApoE concentrations in Turkish adults are significantly linked to serum total cholesterol, hyperapoB, and atherogenic dyslipidemia, independent of the apoE polymorphism. They are also significantly and independently associated with MS. Male carriers of the ε4 allele have no lower apoE concentrations than homozygous ε3 individuals, suggesting a close link between apoE and apoB levels.
Alleles, apolipoproteins B, apolipoproteins E; cholesterol, LDL; dyslipidemias; genotype; metabolic syndrome X
How to cite this article
Altan Onat, Altan Onat, Gülay Hergenç, Erkan Ayhan, Zekeriya Kaya, Zekeriya Küçükdurmaz, Serkan Bulur, Günay Can, Nihan Erginel Ünaltuna. Serum apolipoprotein E concentrations among Turks: information additive to genotype relative to dyslipidemia and metabolic syndrom. Turk Kardiyol Dern Ars. 2007; 35(8): 449-457
Corresponding Author: Altan Onat, Türkiye