Archives of the Turkish Society of Cardiology
Lipid profile, familial hypercholesterolemia prevalence, and 2-year cardiovascular outcome assessment in acute coronary syndrome: Real-life data of a retrospective cohort [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2019; 47(6): 476-486 | DOI: 10.5543/tkda.2019.07360

Lipid profile, familial hypercholesterolemia prevalence, and 2-year cardiovascular outcome assessment in acute coronary syndrome: Real-life data of a retrospective cohort

Meral Kayıkçıoğlu1, Bahadır Alan2, Serdar Payzın2, Levent Hürkan Can2
1Ege University Medical School, Department Of Cardiology, Izmir
2Okan University Medical School, Department Of Cardiology, Istanbul


OBJECTIVE
The aim of this retrospective study based on real-life data was to evaluate the lipid profile and demographic, clinical, and laboratory features of patients with acute coronary syndrome (ACS) at a tertiary center and to examine the mortality rate.

METHODS
Information including endpoint data for at least 2 years following the index ACS event was retrieved from hospital records. Patients without sufficient follow-up data were called by phone. Modified Dutch Lipid Clinic Network criteria were used to identify the presence of familial hypercholesterolemia (FH). Factors affecting mortality in the 2-year follow-up period were evaluated using Cox regression analysis.

RESULTS
A total of 985 ACS patients (215 females) between 21 and 93 years of age were included. The females were older and had a lower smoking rate than the males. In females, the history of obesity and hypertension, the diabetes rate, and the thyroid-stimulating hormone level were higher than those of the males. In 95.6% of the patients, lipid parameters were measured upon hospital admission. No significant difference in dyslipidemia frequency was observed between genders. The frequency of FH was 7.6%. The rate of lipid-lowering drug use was <20% at admission, >90% at discharge, and decreased to 50% in the follow-up period. The mortality rate was 3.8% in the in-hospital period and 8.1% during the 2 years of follow-up.

CONCLUSION
The mortality rate in ACS patients was 3.8% in the in-hospital period and 8.1% in the 2-year follow-up period. The frequency of hypercholesterolemia was 89.5% and the rate of lipid-lowering drug use was insufficient. Secondary prevention after ACS was not adequately employed even at a tertiary center. The FH frequency was 7.6% and those with FH were observed to have ACS at a younger age than those without.

Keywords: Acute coronary syndrome, familial hypercholesterolemia, low-density lipoprotein cholesterol; secondary prevention; mortality.

How to cite this article
Meral Kayıkçıoğlu, Bahadır Alan, Serdar Payzın, Levent Hürkan Can. Lipid profile, familial hypercholesterolemia prevalence, and 2-year cardiovascular outcome assessment in acute coronary syndrome: Real-life data of a retrospective cohort. Turk Kardiyol Dern Ars. 2019; 47(6): 476-486

Corresponding Author: Meral Kayıkçıoğlu, Türkiye
© Copyright 2019 Archives of the Turkish Society of Cardiology
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