ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
Chronic inhibition of tumor necrosis factor-α with infliximab improves myocardial deformation in parallel with aortic elasticity in rheumatoid arthritis [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(2): 138-148 | DOI: 10.5543/tkda.2015.07337

Chronic inhibition of tumor necrosis factor-α with infliximab improves myocardial deformation in parallel with aortic elasticity in rheumatoid arthritis

Birgül Ay1, Mustafa Gökhan Vural2, Ahmet Göktuğ Ertem3, Göksel Çağırcı4, Ramazan Akdemir5, Tolga Han Efe6, Göksal Keskin1, Ekrem Yeter6
1Department of Internal Medicine, Diskapi Yildirim Beyazit Education And Research Hospital, Ankara, Turkey
2Department of Cardiology, Dr. Munif Islamoglu State Hospital, Kastamonu, Turkey
3Department of Cardiology, Ankara Ataturk Training And Research Hospital, Ankara, Turkey
4Department of Cardiology, Antalya Education And Research Hospital, Antalya, Turkey
5Department of Cardiology, Sakarya University, Sakarya, Turkey
6Department of Cardiology, Diskapi Yildirim Beyazit Education And Research Hospital, Ankara, Turkey


OBJECTIVES
This study investigated the effects of infliximab, a monoclonal antibody against TNFα, on myocardial deformation and aortic elasticity in patients with rheumatoid arthritis (RA), and the association of aortic elasticity with myocardial deformation.

STUDY DESIGN
38 female rheumatoid arthritis (RA) patients and 30 healthy controls were included in the study. Twenty patients received infliximab and 18 patients received prednisolone. Left ventricular (LV) longitudinal, circumferential and radial strain, systolic strain rate and early diastolic strain rate using speckletracking echocardiography, and aortic elasticity using M-mode echocardiography were assessed at baseline and post-treatment.

RESULTS
LV systolic longitudinal basal-, mid-, and apical strain, systolic mid- and apical strain rate, basal-, mid- and apical early strain rate, circumferential systolic apical strain and systolic strain rate were reduced in RA patients compared to controls. Compared to baseline, infliximab treatment increased aortic strain, aortic distensibility and decreased aortic β index. No significant aortic elastic changes were observed with prednisolone treatment. Longitudinal basal- and apical strain, basal-, mid- and apical systolic and diastolic strain rates, circumferential basal systolic strain, radial mid- and apical strain and apical strain rate were increased following infliximab treatment. Infliximab treatment improves aortic elasticity in parallel to myocardial deformation, but no significant association was observed following prednisolone treatment.

CONCLUSION
Myocardial deformation is impaired in RA patients and is related to aortic stiffness. Chronic inhibition of TNFα improves LV deformation in association with aortic elasticity.

Keywords: Aorta, echocardiography, myocardial deformation; rheumatoid arthritis/drug therapy; Tumor Necrosis Factor-alpha

How to cite this article
Birgül Ay, Mustafa Gökhan Vural, Ahmet Göktuğ Ertem, Göksel Çağırcı, Ramazan Akdemir, Tolga Han Efe, Göksal Keskin, Ekrem Yeter. Chronic inhibition of tumor necrosis factor-α with infliximab improves myocardial deformation in parallel with aortic elasticity in rheumatoid arthritis. Turk Kardiyol Dern Ars. 2015; 43(2): 138-148

Corresponding Author: Ahmet Göktuğ Ertem, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
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0.22
SCImago Journal Rank: 0.348

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