Investigations Plasma Lipoproteins and Apolipoproteins in Turkish Adults: Overall Levels, Associations with Other Risk Parameters and HDL's Role as a Marker of Coronary Risk in Women [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1999; 27(2): 72-79

Investigations Plasma Lipoproteins and Apolipoproteins in Turkish Adults: Overall Levels, Associations with Other Risk Parameters and HDL's Role as a Marker of Coronary Risk in Women

Altan ONAT1, Beytullah Yıldırım2, Nevzat Uslu1, Necmettin GÜRBÜZ1, İbrahim KELEŞ1, Ali ÇETİNKAYA1, Hüseyin Aksu1, Ömer UYSAL1, Vedat SANSOY1
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In a representative sample of Turkish adults comprising 2573 participants of the or i gina! and new cohorts of the Turkish Risk Factor Survey, plasma concentrations of high-density lipoprotein cholesterol (HDL-C), apolipoprotein Al (apoAI) and B were determined and low-density lipoprotein cholesterol (LDL-C) computed. Participants were aged ?:.27 (mean 48 ± ı 2) years. Plasma apolipoprotein AI (apoAI) and apo B values were determined in one-third of the cohort by utilizing radial immunodifusion plates (Behring) concerning antisera of immunized sheep, and total and HDLcholesterol in over 96% by enzyınatic technique utilizing a Reflotron apparatus. A random sample of lipid and lipoprotein values were validated in a reference laboratory. Obtained findings were evaluated after stratification for sex and age groups. Overall mean valuesfor HDL-C were 37 ± 12, and 45 ± ı 3 mg/di in men and women, respectively, for LDL-C 113 ± 30 and 121 ± 34 mg/di, respectively. HDL-C levels were 20% lower in both genders than those of the U.S. white population; they were inversely correlated in women with plasma triglycerides, body mass index, and waist cicumference, in addition to proving to be an independent determinant of coronary heart disease in women alone (p<0.04), odds ratio between lowest and highest quintiles be ing ı .54, after age adjustment. Mean levels for apoAI were 15% lower in men than in women (122 ± 30 and 141 ± 35 mg/d!, respectively). Remarkably, apoB levels in women (127 ± 54 mg/di) were also higher than in men (122 ± 36 mg/dl). These implied slightly low levels of apoAI in both genders and conspicuously high levels of apoB in women. A significant though mild rise of apoAI concentrations with age was noted in both genders, while a steep rise with age was observed in mean apoB levels in women. Mean apoB values remained above -not substantially below - the levels of LDL-cholesterol in both sexes. In conclusion, Turkish men and women possess low levels of HDL-C and apoAI, and men medium to high, women distinctly high levels of LDL-C and apoB -an adverse setting in regard to coronary risk. An independent contribution by low HDL-C levels to the previously observed high coronary risk in women was in fact demonstrated for the first time.

Keywords: Apolipoproteins, coronary heart disease risk, epidemiology. lipoprote ins, risk factors, Turkish adults

How to cite this article
Altan ONAT, Beytullah Yıldırım, Nevzat Uslu, Necmettin GÜRBÜZ, İbrahim KELEŞ, Ali ÇETİNKAYA, Hüseyin Aksu, Ömer UYSAL, Vedat SANSOY. Investigations Plasma Lipoproteins and Apolipoproteins in Turkish Adults: Overall Levels, Associations with Other Risk Parameters and HDL's Role as a Marker of Coronary Risk in Women. Turk Kardiyol Dern Ars. 1999; 27(2): 72-79
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