Epicardial fat thickness as associated with left ventricular myocardial performance in patients with newly diagnosed hypertension [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(8): 705-713 | DOI: 10.5543/tkda.2015.95902

Epicardial fat thickness as associated with left ventricular myocardial performance in patients with newly diagnosed hypertension

Abdurrezzak Börekçi1, Mustafa Gür1, Taner Şeker2, Ayşe Kalyoncu Uçar3, Ahmet Oytun Baykan2, Zafer Elbasan2, Hazar Harbalıoğlu2, Hakan Uçar2, Murat Çaylı4
1Department of Cardiology, Kafkas University Faculty of Medicine, Kars, Turkey
2Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey
3Department of Radiology, Çukurova State Hospital, Adana, Turkey
4Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakir, Turkey


OBJECTIVE
Epicardial fat thickness (EFth) is associated with both left ventricular hypertrophy (LVH) and diastolic dysfunction. However, the effect of EFth on myocardial performance is not known. The aim of this study was to investigate the relationship between EFth and tissue Doppler myocardial performance index (TD-MPI), which incorporates both systolic and diastolic left ventricular (LV) function, in newly diagnosed hypertension (HT) patients.

METHODS
A total of 314 consecutive, newly diagnosed HT patients were prospectively included (mean age: 51.9±1.7 years). EFth was measured perpendicularly on the free wall of the right ventricle at the end of the systole in 2 echocardiographic views (parasternal short and long axis). Myocardial performance index (MPI) was calculated using tissue Doppler (TD) echocardiography. Patients were divided into 2 groups according to median TD-MPI levels (TD-MPIlow and TD-MPIhigh).

RESULTS
EFth values of the TD-MPIhigh group were higher than those of the TD-MPIlow group (p<0.05). Patients in the TD-MPIhigh group also had higher age, body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular mass index (LVMI), E/A ratio, and aortic distensibility, compared with the TD-MPIlow group (p<0.05 for all). Multivariate linear regression analysis showed that TD-MPI was independently associated with age (β=0.089, p=0.012), LVMI (β=0.090, p=0.05), E/A (β=-0.118, p=0.005), and EFth (β=0.432, p<0.001).

CONCLUSION
TD-MPI was independently associated with EFth in patients with newly diagnosed HT. EFth may be used as a predictor of impaired LV global functions in patients with normal left ventricular ejection fraction (LVEF) and newly diagnosed HT.

Keywords: Epicardial fat thickness, hypertension, hypertrophy, myocardial performance index

How to cite this article
Abdurrezzak Börekçi, Mustafa Gür, Taner Şeker, Ayşe Kalyoncu Uçar, Ahmet Oytun Baykan, Zafer Elbasan, Hazar Harbalıoğlu, Hakan Uçar, Murat Çaylı. Epicardial fat thickness as associated with left ventricular myocardial performance in patients with newly diagnosed hypertension. Turk Kardiyol Dern Ars. 2015; 43(8): 705-713

Corresponding Author: Taner Şeker, Türkiye
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