Turk Kardiyol Dern Ars. 2015; 43(8): 678-683 | DOI: 10.5543/tkda.2015.87243
Evaluation of arterial elastic parameters in patients with subclinical hypothyroidism
Okmeydanı Training And Research Hospital,department of Cardiology, Istanbul, Turkey
OBJECTIVE Hypothyroidism is associated with increased cardiovascular morbidity and mortality. Subclinical hypothyroidism is one of the most common endocrine diseases among the general population. The aim of the present study was to investigate aortic elastic parameters related to increased cardiovascular risk in patients with subclinical hypothyroidism.
METHODS Fifty patients newly diagnosed with subclinical hypothyroidism and 50 healthy, age- and sex-matched euthyroid controls were included. Following physical examination and routine biochemical analysis, systolic and diastolic diameters of the ascending aorta were measured by transthoracic echocardiography, and aortic elasticity parameters were calculated.
RESULTS Age, gender, and body mass index were similar between the groups. Patients had significantly higher C-reactive protein and thyroid-stimulating hormone levels than the control group (p=0.002 and p<0.001, respectively). Aortic stiffness was significantly higher in patients, but aortic strain values were significantly lower (p<0.001). Aortic stiffness, C-reactive protein, aortic strain, and systolic blood pressure were found to be independent predictors of subclinical hypothyroidism in multivariate logistic regression analysis (p<0.05).
CONCLUSION Subclinical hypothyroidism is associated with impairment of aortic elastic parameters, independent of other cardiovascular risk factors.
Aortic stiffness, aortic strain, atherosclerosis, echocardiography; cardiovascular risk; subclinical hypothyroidism.
How to cite this article
Erdal Belen. Evaluation of arterial elastic parameters in patients with subclinical hypothyroidism. Turk Kardiyol Dern Ars. 2015; 43(8): 678-683
Corresponding Author: Erdal Belen, Türkiye