ISSN 1016-5169 | E-ISSN 1308-4488
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Red cell distribution width is increased in patients with ascending aortic dilatation [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(3): 227-235 | DOI: 10.5543/tkda.2014.77508

Red cell distribution width is increased in patients with ascending aortic dilatation

Barış Güngör, Kazım Serhan Özcan, Fatma Özpamuk Karadeniz, Ahmet Ekmekçi, Ahmet Taha Alpwe, Damirbek Osmonov, Mahmut Uluganyan, Baran Karataş, Ercan Toprak, İzzet Celal Erdinler, Osman Bolca
Department of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbul


OBJECTIVES
The prognostic importance of red cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) in cardiovascular diseases has been shown. Ascending aortic dilatation (AAD) is a common cardiovascular disease and is associated with aortic wall inflammation and cystic degeneration. In this study, we aimed to investigate the relationship between serum levels of RDW, NLR and the presence of AAD.

STUDY DESIGN
Two-hundred consecutive patients with AAD diagnosed by transthoracic echocardiography were prospectively recruited and were compared to 170 age-gendermatched subjects with normal aortic diameters. Complete blood counts (CBCs) were analyzed for hemoglobin, RDW and NLR counts, as well as mean corpuscular volume (MCV). If possible, results of CBC tests within the previous two years were also included and the averages were used.


RESULTS
RDW [median 13.9, interquartile range (IQR) 1.40 vs. median 13.3, IQR 1.05%, p=0.01], NLR (median 2.04, IQR 1.09 vs. median 1.78, IQR 0.90, p=0.01) and high-sensitive Creactive protein (hs-CRP) (median 0.60, IQR 0.80 vs. median 0.44, IQR 0.68 mg/L, p=0.01) levels were significantly higher in the AAD group compared to the control group. In univariate correlation analysis, ascending aortic diameters were correlated with RDW levels (r=0.31, p=0.01), NLR levels (r=0.15, p=0.01) and hs-CRP levels (r=0.12, p=0.03). In multivariate logistic regression analysis, increased levels of RDW and hs- CRP remained as the independent correlates of AAD in the study population. Receiver operating characteristic (ROC) curve analysis revealed that a RDW measurement higher than >13.8% predicted AAD with a sensitivity of 49.5% and a specificity of 82.8% (area under the curve [AUC] 0.681, p=0.01).

CONCLUSION
In patients with AAD, RDW and hs-CRP levels are increased, which may indicate the role of inflammation in the pathogenesis of AAD.

Keywords: Ascending aortic dilatation, C-reactive protein/metabolism; echocardiography; erythrocyte indices; red cell distribution width; ROC curve.

How to cite this article
Barış Güngör, Kazım Serhan Özcan, Fatma Özpamuk Karadeniz, Ahmet Ekmekçi, Ahmet Taha Alpwe, Damirbek Osmonov, Mahmut Uluganyan, Baran Karataş, Ercan Toprak, İzzet Celal Erdinler, Osman Bolca. Red cell distribution width is increased in patients with ascending aortic dilatation. Turk Kardiyol Dern Ars. 2014; 42(3): 227-235

Corresponding Author: Kazım Serhan Özcan, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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