Turk Kardiyol Dern Ars. 2018; 46(6): 439-445 | DOI: 10.5543/tkda.2018.75133
Influence of smoking habits on acute outcome of revascularization of chronic total occlusion
, Christian Blockhaus1
, Ruben Jansen1
, Johannes Stein1
, Julian Kürvers1
, Mathias Lehmann1
, Knut Kröger2
, Alexander Bufe11
Heartcentre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany2
Department of Angiology, Helios Clinic Krefeld, Krefeld, Germany
OBJECTIVE Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) remains a major challenge in interventional cardiology. The exact toxic components of cigarette smoke and the mechanisms involved in smoking-related cardiovascular dysfunction are largely unknown, but it increases inflammation, thrombosis, and oxidation of low-density lipoprotein cholesterol. There is only insignificant knowledge reported in the literature about the influence of smoking habits on acute outcome in CTO PCI.
METHODS Between 2012 and 2017, a total of 559 patients were included in the study. The patients all underwent PCI for at least 1 CTO. Antegrade and retrograde CTO techniques were applied. The Shapiro-Wilk test was used to test for normality of distribution. Continuous variables were tested for differences with the KruskalWallis test or the MannWhitney U test, as appropriate. Categorical variables were tested using Fishers exact test.
RESULTS Non-smokers were older than smoking patients (65.3±10.3 years vs. 58.3±9.2 years; p<0.001). The mean age of the cohort was 62.1 years (±10.5). Smokers were more often male (85.7% vs. 79.7%; p=0.074), suffered from longer lesion length (36.1±17.5 mm vs. 39.1±17.2 mm; p=0.023) and therefore needed longer stents (64.2±26.5 mm vs. 69.0±28.0 mm; p=0.084). The success rate was comparable for smokers and non-smokers. In-hospital procedural complications were rare and demonstrated no statistically significant difference.
CONCLUSION The results of this retrospective study revealed no significant association between smoking and acute outcome in CTO PCI. Smokers did, however, have longer lesions and needed longer stents.
Chronic total occlusion, percutaneous coronary intervention; smoking habits.
How to cite this article
Jan-erik Guelker, Christian Blockhaus, Ruben Jansen, Johannes Stein, Julian Kürvers, Mathias Lehmann, Knut Kröger, Alexander Bufe. Influence of smoking habits on acute outcome of revascularization of chronic total occlusion. Turk Kardiyol Dern Ars. 2018; 46(6): 439-445
Corresponding Author: Jan-erik Guelker, Germany