ISSN 1016-5169 | E-ISSN 1308-4488
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The relationship between epicardial adipose tissue and endothelial dysfunction in patients with type 2 diabetes mellitus [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(5): 450-455 | DOI: 10.5543/tkda.2014.72772

The relationship between epicardial adipose tissue and endothelial dysfunction in patients with type 2 diabetes mellitus

Ahmet Çelik1, Mustafa Topuz2, Yavuz Gözükara3, Ahmet Gündeş1, Emrah Yeşil1, Didem Ovla4, İsmail Türkay Özcan1
1Department Of Cardiology, Mersin University, Mersin, Turkey
2Department Of Cardiology, Adana Numune Hospital, Adana, Turkey
3Department Of Internal Disease, Mersin State Hospital, Mersin, Turkey
4Department Of Biostatistics, Mersin University, Mersin, Turkey


OBJECTIVES
Epicardial adipose tissue (EAT) has been shown to be related to cardiovascular risk. The aim of the present study was to investigate the relationship between EAT and endothelial function in patients with type 2 diabetes mellitus (DM).

STUDY DESIGN
Type 2 DM patients were divided into two groups according to their brachial flow-mediated dilatation (FMD) values. The endothelial dysfunction (ED) group consisted of 46 patients with FMD change of <7%, while 46 patients with FMD change of >7% were accepted as the non-ED group. EAT thickness was measured on the right ventricular free wall from the transthoracic echocardiographic parasternal long- and short-axis views. The patients’ demographic, anthropometric and laboratory findings were recorded.

RESULTS
The mean diameter of EAT was 8.0±1.8 cm in the ED group and 6.6±1.2 cm in the non-ED group (p<0.001). The HbA1c levels were significantly higher in the ED group than non-ED group (8.55 [7.30-9.80], 7.45 [6.50-9.30], respectively; p=0.042). There were a negative correlation between FMD values and EAT (r=-0.437, p<0.001). The FMD values were weakly and negatively correlated with DM duration and HbA1c levels (r=-0.216, p=0.038; r=-0.266, p=0.010, respectively). EAT thickness was strongly correlated with body mass index (BMI) and waist length (r=0.405, p<0.001; r=0.515, p<0.001, respectively). The neutrophil count was significantly higher in the ED group than in the non-ED group. In multivariate logistic regression analysis, HbA1c and EAT diameters were found as predictors of ED in type 2 DM (odds ratio (OR): 1.887, 95% confidence interval (CI): 1.298-2.743, p=0.001; OR: 1.485, 95% CI: 1.054-2.093).

CONCLUSION
EAT thickness predicts ED in patients with type 2 DM.

Keywords: The relationship between epicardial adipose tissue and endothelial dysfunction in patients with type 2 diabetes mellitus

How to cite this article
Ahmet Çelik, Mustafa Topuz, Yavuz Gözükara, Ahmet Gündeş, Emrah Yeşil, Didem Ovla, İsmail Türkay Özcan. The relationship between epicardial adipose tissue and endothelial dysfunction in patients with type 2 diabetes mellitus. Turk Kardiyol Dern Ars. 2014; 42(5): 450-455

Corresponding Author: Ahmet Çelik, Türkiye
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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