ISSN 1016-5169 | E-ISSN 1308-4488
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A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(7): 648-650 | DOI: 10.5543/tkda.2015.65848

A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments

Mustafa Adem Tatlısu1, Elif İjlal Çekirdekçi2, Şükrü Akyüz3, Zekeriya Nurkalem4
1Department of Cardiology, Sivas Numune State Hospital, Sivas, Turkey
2Department of Cardiology, Corlu State Hospital, Tekirdağ, Turkey
3Department of Cardiology, Dr. Siyami Ersek Cardiovascular And Thoracic Surgery Hospital, İstanbul, Turkey
4Department of Cardiology, Istanbul Medipol University, İstanbul, Turkey

Nerium oleander is a popular ornamental plant grown in many tropical and subtropical countries and in the Mediterranean region. It is dangerous because it has been shown to contain several types of cardiac glycosides, and hence can cause cardiac arrhythmias resembling digoxin in their toxicologic manifestations. We report a patient presenting to our hospital with Mobitz type II atrioventricular block after drinking herbal tea prepared from oleander leaves. Three hours after admission, a 200-mg empiric dose of digoxin-specific Fab antibody fragments was administered intravenously over 30 minutes. A 12-lead electrocardiogram (ECG) revealed sinus rhythm at the end of infusion. After 72 hours, the patient was discharged without any symptoms.

Keywords: Atrioventricular block, Nerium oleander, digoxin/adverse effects

How to cite this article
Mustafa Adem Tatlısu, Elif İjlal Çekirdekçi, Şükrü Akyüz, Zekeriya Nurkalem. A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments. Turk Kardiyol Dern Ars. 2015; 43(7): 648-650

Corresponding Author: Mustafa Adem Tatlısu, Türkiye
Manuscript Language: English


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