ISSN 1016-5169 | E-ISSN 1308-4488
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Assessment of left ventricular systolic and diastolic function with conventional and tissue Doppler echocardiography imaging techniques in patients administered tyrosine kinase inhibitor [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(7): 597-605 | DOI: 10.5543/tkda.2012.53896

Assessment of left ventricular systolic and diastolic function with conventional and tissue Doppler echocardiography imaging techniques in patients administered tyrosine kinase inhibitor

Yusuf İzzettin Alihanoğlu1, Zeynettın Kaya2, Hatem Arı3, Şükrü Karaarslan4, Bekir Serhat Yıldız1, Mustafa Karanfil5, Mehmet Yazıcı5, Melih Cem Börüban6, Kurtuluş Özdemir5, Mehmet Sıddık Ülgen7
1Department of Cardiology, Denizli State Hospital, Denizli, Turkey
2Department of Cardiology, Numune State Hospital, Konya, Turkey
3Department of Cardiology, Beyhekim State Hospital, Konya, Turkey
4Department of Cardiology, Nigde State Hospital, Nigde, Turkey
5Department of Cardiology Selcuk University, Meram Faculty of Medicine, Konya, Turkey
6Department of Oncology, Selcuk University, Meram Faculty of Medicine, Konya, Turkey
7Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakir, Turkey


OBJECTIVES
The aim of this study was to use echocardiographic techniques to determine the possible cardiotoxic effects of low molecular weight tyrosine-kinase inhibitors (TKI) in patients receiving the therapy for the first time.

STUDY DESIGN
Thirty patients (17 females; 13 males; mean age 49±16; range 22 to 76 years) who met the exclusion criteria and were diagnosed as having malignancy were enrolled. All patients underwent conventional echocardiography and tissue Doppler imaging (TDI) prior to the treatment. The conventional echocardiogram was repeated 2 months later as the patients were concurrently receiving therapy. Myocardial Performance Index was obtained by conventional echocardiography and by TDI techniques to evaluate left ventricular systolic and diastolic function.

RESULTS
Statistically significant increase occurred in mean left ventricle (LV) end-systolic volume. However, there was significant decrease in both mean LV ejection fraction and LV stroke volume values (64±3, 62±4, p=0.000 and 67±13, 61±13, p=0.000, respectively). Anterior wall Em/Am ratio measured by using the TDI technique was significantly decreased at the end of two months (0.99±0.49, 0.90±0.41, p=0.03). In addition, decreases were determined in Sm values obtained from all of four LV walls and also in mean Sm value, but this decrease was significant only for the lateral wall Sm measurement (12.8±2.9, 11.6±2.3, p=0.004).

CONCLUSION
Tyrosine-kinase inhibitors therapy can be administered safely to patients without predisposing factors for cardiotoxicity in short treatment intervals, and low molecular TKIs may cause subtle or clinically significant cardiotoxicity following the treatment period even in patients without predisposing factors for cardiotoxicity, so clinicians should consider this possibility.

Keywords: Cardiotoxicity, echocardiography, Doppler; elasticity imaging techniques; heart failure/chemically induced; drug interactions; neoplasms/drug therapy; protein-tyrosine kinases/antagonists & inhibitors; ventricular function, left

How to cite this article
Yusuf İzzettin Alihanoğlu, Zeynettın Kaya, Hatem Arı, Şükrü Karaarslan, Bekir Serhat Yıldız, Mustafa Karanfil, Mehmet Yazıcı, Melih Cem Börüban, Kurtuluş Özdemir, Mehmet Sıddık Ülgen. Assessment of left ventricular systolic and diastolic function with conventional and tissue Doppler echocardiography imaging techniques in patients administered tyrosine kinase inhibitor. Turk Kardiyol Dern Ars. 2012; 40(7): 597-605

Corresponding Author: Yusuf İzzettin Alihanoğlu, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
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SCImago Journal Rank: 0.348

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