ISSN 1016-5169 | E-ISSN 1308-4488
Increased aortic pulse wave velocity in obese children [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(7): 557-562 | DOI: 10.5543/tkda.2011.01694

Increased aortic pulse wave velocity in obese children

Ataç Çelik1, Mustafa Özçetin2, Yasemin Yerli2, İbrahim Halil Damar1, Hasan Kadı1, Fatih Koç1, Köksal Ceyhan1
1Department of Cardiology, Gaziosmanpasa University, Tokat, Turkey
2Department of Pediatrics, Gaziosmanpasa University, Tokat, Turkey

Obesity may start in childhood and obese children are more likely to grow up to be obese adults. Atherosclerosis is one of the most important complications of obesity. Pulse wave velocity (PWV), a noninvasive measure of arterial stiffness, is accepted to be an indicator of subclinical atherosclerosis. The aim of the study was to determine PWV in obese children.

The study included 30 obese (12 boys, 18 girls; mean age 13±2 years) and 30 lean children (13 boys, 17 girls; mean age 12.5±1.7 years). Weight and height were measured and obesity was defined as body mass index (BMI) of greater than the 95th percentile for age. All the subjects underwent echocardiographic evaluation and blood samples were obtained. Pulse-wave velocity was calculated using the following equation: PWV (m/sec) = height-based aortic length (cm)/(100xtransit time [sec]). The latter was measured as the difference in the time of onset of two flows at the diaphragm and the aortic valve.

Obese subjects had significantly higher blood pressure levels compared to the control group (p<0.001). The two groups were similar with respect to fasting glucose, hemoglobin, serum creatinine, and lipid levels. Among echocardiographic parameters, left ventricular end-diastolic dimension, interventricular septum thickness, posterior wall thickness, left ventricular mass index, left atrium dimension, and aortic root dimension were significantly increased in obese subjects compared to controls (p<0.01). Obese children had significantly higher PWV values than the controls (4.0±0.8 vs. 3.3±0.7 m/sec, p<0.001). A positive significant correlation was found between PWV and BMI (r=0.391, p=0.002).

Our findings show that aortic PWV is increased in obese children, suggesting that obesity may cause subclinical atherosclerosis even at early ages.

Keywords: Adolescent, atherosclerosis/etiology; echocardiography, Doppler, pulsed/methods; elasticity; obesity/complications; vascular resistance

How to cite this article
Ataç Çelik, Mustafa Özçetin, Yasemin Yerli, İbrahim Halil Damar, Hasan Kadı, Fatih Koç, Köksal Ceyhan. Increased aortic pulse wave velocity in obese children. Turk Kardiyol Dern Ars. 2011; 39(7): 557-562

Corresponding Author: Ataç Çelik, Türkiye
Manuscript Language: English

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