ISSN 1016-5169 | E-ISSN 1308-4488
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Effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(2): 147-153 | DOI: 10.5543/tkda.2014.13463

Effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits

Artan Jahollari1, Anar Emrahov2, Murat Tavlaşoğlu3, Mustafa Kürklüoğlu2, Mehmet Ali Şahin2, Adem Güler2, Ertuğrul Özal1, Mehmet Arslan2
1Medical Park Hospital, Cardiovascular Surgery Department, Samsun
2Gülhane Military Medicine Academy, Cardiovascular Surgery Department, Etlik, Ankara
3Diyarbakır Military Hospital, Cardiovascular Surgery Department, Diyarbakır


OBJECTIVES
We investigated the effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits.

STUDY DESIGN
Eighteen New Zealand male rabbits were randomized into two groups, as drug (Group B) and non-drug (Group A). The right carotid artery of all the subjects was transected and anastomosed end-to-end with 10/0 polypropylene suture. The left carotid artery was left intact. Group B subjects received 30 mg/kg/day oral bosentan for 21 days, starting 3 days before the operation. Group A subjects did not receive any medication. After 28 days, the anastomoses site and the contralateral control site were removed, and samples were investigated histomorphometrically.

RESULTS
Significant intimal hyperplasia was observed at all anastomoses compared to the non-anastomotic left side. Bosentan decreased significantly the intimal area [Group A: 48.3 μm2 (37.1 μm2-65.7 μm2), Group B: 31.4 μm2 (12.2 μm2- 63.2 μm2), (p=0.04)] and intima/media area ratio [Group A: 0.49 (0.13-0.74), Group B: 0.22 (0.09-0.37), (p=0.024)] compared to the non-drug group.

CONCLUSION
According to our investigation, bosentan decreased the intimal hyperplasia developed in a rabbit carotid artery model. Further investigations are needed to support the potential clinical utilization of bosentan after vascular interventions.

Keywords: Bosentan, endothelin-1; endothelin receptor antagonist; animals; hyperplasia; immunohistochemistry; carotid arteries/growth & development; receptors, endothelin; rabbits, New Zealand.

How to cite this article
Artan Jahollari, Anar Emrahov, Murat Tavlaşoğlu, Mustafa Kürklüoğlu, Mehmet Ali Şahin, Adem Güler, Ertuğrul Özal, Mehmet Arslan. Effect of bosentan on intimal hyperplasia of carotid artery anastomoses in rabbits. Turk Kardiyol Dern Ars. 2014; 42(2): 147-153

Corresponding Author: Artan Jahollari, Türkiye
Manuscript Language: Turkish


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