Diastolic functions and myocardial performance index in obese patients with or without metabolic syndrome: a tissue Doppler study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2010; 38(6): 400-404

Diastolic functions and myocardial performance index in obese patients with or without metabolic syndrome: a tissue Doppler study

Fatih Koc1, Mehmet Tokac2, Coskun Kaya3, Mehmet Kayrak2, Mehmet Yazici2, Turgut Karabag2, Mehmet Akif Vatankulu2, Selim Ayhan2, Kenan Demir2
1Department of Cardiology, Gaziosmanpasa University, Tokat, Turkey
2Department of Cardiology, Selcuk University, Konya, Turkey
3Department of Internal Medicine, Selcuk University, Konya, Turkey


OBJECTIVES
This study was designed to evaluate left ventricular (LV) diastolic functions and myocardial performance index (MPI) in obese individuals with or without metabolic syndrome (MetS).

STUDY DESIGN
The study included 44 obese subjects with MetS (16 men; 28 women; mean age 46±7 years) and 32 obese subjects without MetS (16 men, 16 women; mean age 43±9 years). Diagnosis of MetS was based on the ATP III criteria. Obesity was defined with a body mass index (BMI) of ≥30 kg/m2. All the subjects underwent echocardiography and tissue Doppler imaging to determine LV diastolic functions and MPI. Clinical and echocardiographic characteristics of obese subjects were compared with those of a control group consisting of 21 healthy, nonobese individuals (10 men, 11 women; mean age 42±4 years).

RESULTS
Waist circumference, weight, and BMI were similar in the two obese groups. Control subjects and obese subjects without MetS had similar systolic and diastolic blood pressures, fasting blood glucose, triglyceride, and HDL cholesterol levels, but all these significantly differed in patients with MetS. Left ventricular mass, mass index, and diastolic parameters were similar in the two obese groups, but differed significantly from the controls (p<0.05). Body mass index was correlated with the LV mass (r=0.42, p=0.001) and mass index (r=0.33, p=0.001). Left ventricular MPI was similar in the two obese groups with (0.59±0.10) and without (0.59±0.11) MetS, but was higher compared to the control group (0.48±0.06, p<0.05). Left ventricular MPI was correlated with BMI, waist circumference, LV mass, and mass index (r=0.24, p=0.02; r=0.30, p=0.005; r=0.31, p=0.002; r=0.21, p=0.04, respectively).

CONCLUSION
Our findings demonstrate that obesity with or without MetS affects LV MPI. In addition, LV MPI showed significant correlations with BMI, waist circumference, and LV mass.

Keywords: Echocardiography, Doppler, metabolic syndrome X/complications; myocardial contraction; obesity/complications; ventricular function, left

How to cite this article
Fatih Koc, Mehmet Tokac, Coskun Kaya, Mehmet Kayrak, Mehmet Yazici, Turgut Karabag, Mehmet Akif Vatankulu, Selim Ayhan, Kenan Demir. Diastolic functions and myocardial performance index in obese patients with or without metabolic syndrome: a tissue Doppler study. Turk Kardiyol Dern Ars. 2010; 38(6): 400-404

Corresponding Author: Fatih Koc, Türkiye
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