Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(6): 457-465 | DOI: 10.5543/tkda.2016.10733

Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study

Mehdi Zoghi1, Hakki Kaya2, Yuksel Cavusoglu3, Enbiya Aksakal4, Serafettin Demir5, Ceyhun Yucel6, Hasim Mutlu7, Oktay Ergene8, Mehmet Birhan Yilmaz2, On Behalf Of The Beta Genturk Study1
1Department Of Cardiology, Ege University, Izmir, Turkey
2Department Of Cardiology, Cumhuriyet University, Sivas, Turkey
3Department Of Cardiology,osmangazi University, Eskisehir, Turkey
4Department Of Cardiology, Ataturk University, Erzurum, Turkey
5Department Of Cardiology, Cukurova University, Adana, Turkey
6Cardiology, Cukurova University, Balcalı Hospital, Adana, Turkey
7Department Of Cardiology, Istanbul University, Istanbul, Turkey
8Cardiology, Ataturk Hospital, Izmir, Turkey


OBJECTIVE
The present objective was to determine frequency of Arginine389Glycine (Arg389Gly) and Cytochrome p450 2D6*10 (Cyp2D6*10) polymorphism in cases of heart failure-reduced ejection fraction (HFREF), and to evaluate the influence of the polymorphisms in response to beta-blocker (BB) therapy.

METHODS
A total of 206 HFREF patients and 90 healthy controls were prospectively enrolled. Genotypes for Arg389Gly and Cyp2D6*10 polymorphisms of the healthy controls and 162 of the 206 heart failure (HF) patients were measured, identified by polymerase-chain-reaction- and restriction-fragment-length-polymorphism analysis. HFREF patients and healthy controls were compared regarding Arg389Gly polymorphism. The HFREF patients were separated into 2 subgroups based on achievement of maximal target dose (MTD) of BB.

RESULTS
When comparing frequency of genotype distribution for Arg389Gly polymorphism in HFREF patients to the healthy controls, a statistically significant association was observed with CC genotype and Glisin-Glisin (GG) genotype (p<0.001, odds ratio [OR]=16, confidence interval [CI]: 3.8–67.9 and p<0.001, OR=0.3, CI: 0.2-0.6). Frequency of genotypes for Arg389Gly and Cyp2D6*10 polymorphism were similar in patients who could or could not achieve BB MTD (p=0.13 and p=0.60, respectively).

CONCLUSION
The frequency of Arg389Gly polymorphism in patients with HFREF in the present Turkish population differed from that of the healthy controls. However, neither Arg389Gly polymorphism nor Cyp2D6*10 polymorphism was associated with dose tolerability of BB therapy.

Keywords: Functional capacity, heart failure, medical adherence, socioeconomic status.

How to cite this article
Mehdi Zoghi, Hakki Kaya, Yuksel Cavusoglu, Enbiya Aksakal, Serafettin Demir, Ceyhun Yucel, Hasim Mutlu, Oktay Ergene, Mehmet Birhan Yilmaz, On Behalf Of The Beta Genturk Study. Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study. Turk Kardiyol Dern Ars. 2016; 44(6): 457-465

Corresponding Author: Hakki Kaya, Türkiye
© Copyright 2019 Archives of the Turkish Society of Cardiology
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