ISSN 1016-5169 | E-ISSN 1308-4488
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The Relationship between Serum Neuropeptide FFR2, Serum Smoothelin and Pregnancy Outcomes in Pregnant Women with Gestational Hypertension [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2024; 52(7): 510-518 | DOI: 10.5543/tkda.2024.10241

The Relationship between Serum Neuropeptide FFR2, Serum Smoothelin and Pregnancy Outcomes in Pregnant Women with Gestational Hypertension

Sedat Taş1, Kemal Sarsmaz2, Hayrunnisa Yeşil Sarsmaz3, Seren Gülşen Gürgen4, Ümmü Taş5, Mehmet Eyüboğlu5, Zeki Arı6
1Department of Cardiology, Manisa Celal Bayar University, Manisa, Türkiye
2Department of Obstetrics and Gynecology, Manisa Celal Bayar University, Manisa, Türkiye
3Department of Histology and Embryology, Manisa Celal Bayar University Faculty of Health Sciences, Manisa, Türkiye
4Department of Histology and Embryology, Manisa Celal Bayar University Vocational School of Health Services, Manisa, Türkiye
5Department of Cardiology, İzmir Demokrasi University, İzmir, Türkiye
6Department of Biochemistry, Manisa Celal Bayar University, Manisa, Türkiye


OBJECTIVE
Gestational hypetension is a major public health concern due to its links with cardiovascular disease, stroke and neonatal morbidity and mortality. Timely diagnosis and effective management of gestational hypertension are essential for both maternal and neonatal health. Neuropeptide FF Receptor 2 (NPFFR2) is a protein secreted by the brain and placenta, involved in pain regulation, water balance, and the modulation of cardiovascular effects. This study aims to conduct a comparative analysis of NPFFR2, smoothelin (SMTH), echocardiographic results and pregnancy outcomes in pregnant women with and without gestational hypertension.


METHOD
This study included 78 pregnant participants, which were grouped into women with gestational hypertension (n = 39) and those without gestational hypetension (n = 39). The gestational hypertension population was classified into two groups, i.e., dipper and non-dipper groups, based on the 24-hour ambulatory blood pressure monitoring results. Smoothelin and NPFFR2 analyses were performed using the blood samples and placental tissue samples collected from all participants, along with echocardiography and 24-hour ambulatory blood pressure monitoring.


RESULTS
The study group comprised 78 pregnant women with a mean age of 28.8 years and mean gestational age of 27.7 weeks. The gestational hypertension group had a significantly higher NPFFR2 levels, lower SMTH levels and gestational age at birth and higher all 24-hour ambulatory blood pressure monitoring findings. The left atrial-to-aortic ratio and Tricuspid annular plane systolic excursion (TAPSE) were significantly higher in GİH group than in the control group. NPFFR2 and gestational age at birth were found to be independently associated with neonatal intensive care unit admission.


CONCLUSION
Serum NPFFR2 levels were increased in women with gestational hypertension, SMTH levels were decreased, and pregnancy prognosis was found to be associated with NPFFR2 levels.

Keywords: Hypertension, neuropeptide FF (NPFF), neuropeptide FFR2, syncytin, pregnancy, neonatal outcome

Corresponding Author: Sedat Taş
Manuscript Language: Turkish
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Journal Citation Indicator: 0.18
CiteScore: 1.1
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SCImago Journal Rank: 0.348

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