The Role of Angiotensin Converting Enzyme Gene Polymorphism in the Development of Premature Coronary Artery Disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2004; 32(1): 23-27

The Role of Angiotensin Converting Enzyme Gene Polymorphism in the Development of Premature Coronary Artery Disease

Tamer AKBULUT1, Tuba BİLSEL1, Hüseyin UYAREL1, Sait TERZİ1, Nurten SAYAR1, Alper AYDIN1, Şennur Ünal DAYİ1, Figen ÇİLOĞLU2, Bayram BAĞIRTAN1, İsmail PEKER3, Kemal YEŞİLÇİMEN1
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Angiotensin-converting enzyme (ACE) gene polymorphism has been associated with many cardiovascular pathologies. The goal of our study was to assess the association of ACE gene polymorphism with premature coronary artery disease in Turkish population sample. A total of 139 young patients (?50 years) with coronary artery disease were evaluated in regard to ACE gene polymorphism and conventional coronary risk factors. The findings were analyzed and compared with those of 67 healthy young persons. Both allele frequencies and ACE genotype distribution did not differ substantially between groups (ACE I/I: %13.7; ACE I/D: %59; ACE D/D: %27.3 in the study group and; ACE I/I: %17.9, ACE I/D: %57.2, ACE D/D: %27.9 and in the control group). The odds ratios were 0.88 for D homozygotes (p > 0.05) and 1.03 for the D allele (p > 0.05). On the other hand, the other variables (smoking, plasma cholesterol level, obesity, and diabetes mellitus) were found to be related to the development of premature coronary artery disease.
CONCLUSION
ACE gene polymorphism does not seem to be associated with premature coronary artery disease in the studied, limited-sized Turkish sample population. (Türk Kardiyol Dern Arş 2004; 32: 23-27)

Keywords: ACE genotype, premature coronary artery disease

How to cite this article
Tamer AKBULUT, Tuba BİLSEL, Hüseyin UYAREL, Sait TERZİ, Nurten SAYAR, Alper AYDIN, Şennur Ünal DAYİ, Figen ÇİLOĞLU, Bayram BAĞIRTAN, İsmail PEKER, Kemal YEŞİLÇİMEN. The Role of Angiotensin Converting Enzyme Gene Polymorphism in the Development of Premature Coronary Artery Disease. Turk Kardiyol Dern Ars. 2004; 32(1): 23-27
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