ISSN 1016-5169 | E-ISSN 1308-4488
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Primary angioplasty in women with ST-elevation myocardial infarction: in-hospital and long-term clinical results [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(2): 114-121 | DOI: 10.5543/tkda.2011.01244

Primary angioplasty in women with ST-elevation myocardial infarction: in-hospital and long-term clinical results

Erkan Ayhan1, Hüseyin Uyarel2, Mehmet Ergelen1, Gökhan Çiçek1, Emre Akkaya1, Zeki Günaydın1, Turgay Işık1, Damirbek Osmonov1, Ayça Türer1, Ceyhan Türkkan1, Mehmet Bozbay1, Ahmet Narin1
1Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Cardiology Department, Istanbul, Turkey
2Balıkesir University Medical School of Medicine, Cardiology Department, Balikesir, Turkey


OBJECTIVES
We evaluated in-hospital and long-term clinical results of female patients following primary angioplasty for ST-elevation myocardial infarction (STEMI), in comparison with male patients.

STUDY DESIGN
We reviewed 2,644 patients (2,188 males, 456 females) who underwent primary angioplasty for STEMI between October 2003 and March 2008. Data on female patients concerning demographic and clinical characteristics, primary angioplasty results, in-hospital and 25-month follow-up results were compared with those of male patients.

RESULTS
Hypertension, diabetes mellitus, anemia, shock, and renal failure were more common in female patients, while smoking was more frequent in males (p<0.05). The mean age was higher in female patients (63.9±11.7 vs. 55.2±11.3, p<0.001). Females also presented with higher values of glucose, mean platelet volume, and platelet count, and lower hemoglobin and hematocrit values (p<0.05). The frequencies of multivessel disease and procedure failure were significantly higher, and pain-to-balloon time was significantly longer in females (p<0.05). Mortality associated with cardiovascular causes occurred in 148 patients (5.6%), being significantly higher in females (9.4% vs. 4.8%, p<0.001). In-hospital mortality, major cardiac events, stroke, cardiogenic shock, and major bleeding were more frequent in women (p<0.05). Long-term mortality rate was also significantly higher in females (10% vs. 4.5%, p<0.001). Multivariate analysis showed female gender as one of the independent predictors of mortality (odds ratio=1.75, 95% CI 1.02-2.99; p<0.04).

CONCLUSION
Female patients with STEMI undergoing primary angioplasty have a higher risk profile and poorer in-hospital and follow-up clinical results. Therefore, female patients should be treated more aggressively.

Keywords: Angioplasty, balloon, coronary, female; hospital mortality; myocardial infarction/therapy/mortality; sex factors

How to cite this article
Erkan Ayhan, Hüseyin Uyarel, Mehmet Ergelen, Gökhan Çiçek, Emre Akkaya, Zeki Günaydın, Turgay Işık, Damirbek Osmonov, Ayça Türer, Ceyhan Türkkan, Mehmet Bozbay, Ahmet Narin. Primary angioplasty in women with ST-elevation myocardial infarction: in-hospital and long-term clinical results. Turk Kardiyol Dern Ars. 2011; 39(2): 114-121

Corresponding Author: Erkan Ayhan, Türkiye
Manuscript Language: Turkish


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Journal Citation Indicator: 0.18
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