ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Türk Yetişkinlerde Kesitsel bir İncelemede, Serum Total Fosfolipidlerin Metabolik Sendrom ve Koroner Risk ile ilişkileri [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2004; 32(3): 168-177

Türk Yetişkinlerde Kesitsel bir İncelemede, Serum Total Fosfolipidlerin Metabolik Sendrom ve Koroner Risk ile ilişkileri

Altan ONAT1, Gülay HERGENÇ1, Bülent UZUNLAR1, İbrahim SARI1, Serdar TÜRKMEN1, Hüseyin UYAREL1, Mehmet YAZICI1, İbrahim KELEŞ1, Vedat SANSOY1
Türk Kardiyoloji Derneği, Yıldız Teknik Üniversitesi, S. Ersek Kalp-Damar Cerrahisi Merkezi, Gaziantep Ü. Tıp Fakültesi, İ. Baysal Ü. Düzce Tıp Fakültesi, İ. Ü. Cerrahpaşa Tıp Fakültesi ve Kardiyoloji Enstitüsü, İstanbul

Phospholipids, constituents of the outer layer of all lipoproteins and cell membranes, have not been measured in epidemiological studies, due to their heterogeneity. Rather, the specific phospholipid subgroups have lately been investigated. Phosholipids and oxidized phospholipids are biologically active molecules and are involved in atherogenesis as well as inflammatory processes and immune responses. In the 2003 screening of the Turkish Adult Risk Factor Study, phospholipids were measured firstly in 452 men and women in the Marmara and Central Anatolian regions. A method that measures the total phosphatidylcholine, sphingomyelin and lyso-phosphatidylcholine was used. Coronary heart disease (CHD) and metabolic syndrome (MS) were encountered in 11.3% and 45.4% of the cohort, respectively. Serum phospholipid levels were found to be significantly different between men (192.2±32.0 mg/dl) and women (204.9±41.2 mg/d). Significant correlations existed between serum phospholipid levels and total cholesterol, apo AII, triglycerides, LDL-C, complement C3, apo B, apo AI and coronary risk score (r>0. 30), HDL-C, diastolic BP, body mass index, metabolic syndrome, waist circumference, fibrinogen, log CRP, log GGT, glucose (r =0. 10 to. 25), uric acid, log fasting insulin and, inversely, with smoking and physical activity (r =-0. 10), and (at borderline significance) with age. Multiple linear regression analysis among 13 risk parameters revealed triglycerides, LDL-C, HDL-C, and complement C3 as independent significant determinants of phospholipid levels. Sex- and age-adjusted OR of phospholipid levels were not found to be significant for prevalant coronary heart disease. Age-adjusted OR of phospholipid levels for metabolic syndrome were found to be significant only in men with 1. 013 (%95 1.002;1.023). We conclude that high total phospholipid levels reflect high risk for metabolic syndrome, particularly in men, though these are not independent of the standard components. The age-adjusted risk of these levels in association with CHD which exhibited a trend among women, requires further investigation in the future. Studying their content in the HDL fraction or the specific phospholipids and their oxidized forms in different lipoprotein frac-tions seem more promising in this regard. (Türk Kardiyol Dern Arş 2004; 32: 168-177)

Anahtar Kelimeler: Fosfolipidler, epidemiyoloji, koroner kalp hastalığı, metabolik sendrom

Serum Total Phospholipid Levels in Turkish Adults: A Cross Sectional Study on Associations With Risk of Metabolic Syndrome and Coronary Disease

Bu makaleye nasıl atıfta bulunacaksınız?
Altan ONAT, Gülay HERGENÇ, Bülent UZUNLAR, İbrahim SARI, Serdar TÜRKMEN, Hüseyin UYAREL, Mehmet YAZICI, İbrahim KELEŞ, Vedat SANSOY. Serum Total Phospholipid Levels in Turkish Adults: A Cross Sectional Study on Associations With Risk of Metabolic Syndrome and Coronary Disease. Turk Kardiyol Dern Ars. 2004; 32(3): 168-177
Makale Dili: Türkçe


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