Archives of the Turkish Society of Cardiology
Disseminated adenovirus infection in heart and kidney transplant [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2018; 46(3): 231-233 | DOI: 10.5543/tkda.2017.74957

Disseminated adenovirus infection in heart and kidney transplant

Jack Xu1, Keval V Patel2, Melroy Dsouza3, Jesus Almendral2, Kanika Mody2, Deepa Iyer2
1Department of Internal Medicine, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA
2Department of Cardiology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA
3Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA

Presently described is a case of disseminated adenovirus infection in a heart-kidney transplant recipient that was successfully treated with cidofovir. There are several reports of adenovirus infections in adult solid organ transplant recipients and the prognosis is usually poor, with mortality rates of 40% to 60%. Severe disseminated adenovirus infections have been associated with increased risk of adverse transplant events, such as rejection, ventricular dysfunction, allograft vasculopathy, graft loss, and the need for re-transplantation. The patient’s lack of clinical improvement, the onset of hemorrhagic cystitis and acute kidney injury were factors in our decision to temporarily discontinue administration of immunosuppressive agents and start an antiviral agent. It is important to suspect adenovirus in transplant patients when they do not respond to antibiotics and cultures are negative. Early diagnosis and treatment are critical to improving outcomes in immunocompromised patients.

Keywords: Disseminated adenovirus, heart and kidney transplant; transplant recipient.

How to cite this article
Jack Xu, Keval V Patel, Melroy Dsouza, Jesus Almendral, Kanika Mody, Deepa Iyer. Disseminated adenovirus infection in heart and kidney transplant. Turk Kardiyol Dern Ars. 2018; 46(3): 231-233

Corresponding Author: Jack Xu, United States
© Copyright 2018 Archives of the Turkish Society of Cardiology
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