Archives of the Turkish Society of Cardiology
Rationale, design, and methodology of the Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2018; 46(1): 47-53 | DOI: 10.5543/tkda.2017.73861

Rationale, design, and methodology of the Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia

Volkan Doğan1, Özcan Başaran1, Bülent Özlek1, Oğuzhan Çelik1, Eda Özlek1, Kadir Uğur Mert2, İbrahim Rencüzoğulları3, Gurbet Özge Mert4, Marwa Mouline Doğan1, Murat Biteker1, Meral Kayıkçıoğlu5
1Department of Cardiology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey
2Department of Cardiology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey
3Department of Cardiology, Kafkas University Faculty of Medicine, Kars, Turkey
4Department of Cardiology, Eskişehir Yunus Emre State Hospital, Eskişehir, Turkey
5Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey


OBJECTIVE
A wide gap exists between dyslipidemia guidelines and their implementation in the real world, which is primarily attributed to physician and patient compliance. The aim of this study is to determine physician and patient adherence to dyslipidemia guidelines and various influential factors.

METHODS
The Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia (EPHESUS) trial (ClinicalTrials.gov number NCT02608645) will be an observational, multicenter, non-interventional study. The study targets enrollment of 2000 patients from 50 locations across Turkey. All of the data will be collected in a single visit and current clinical practice will be evaluated. A cross-sectional survey of public perception and knowledge of cholesterol treatment among Turkish adults will be performed. All consecutive patients admitted to cardiology clinics who are in the secondary prevention group (coronary heart disease, peripheral artery disease, atherosclerotic cerebrovascular disease) and who are in the high-risk primary prevention group (type 2 diabetes mellitus with no prior known coronary heart disease; patients who had markedly elevated single risk factors, in particular, cholesterol >8 mmol/L [>310 mg/dL], blood pressure ≥180/110 mmHg, a calculated Systematic Coronary Risk Evaluation [SCORE] ≥5%, or <10% 10-year risk of fatal cardiovascular disease) will be included. Demographic, lifestyle, medical, and therapeutic data will be collected with a survey designed for the study.

CONCLUSION
The EPHESUS registry will be the largest study conducted in Turkey evaluating the adherence to dyslipidemia guidelines both in secondary and high-risk primary prevention patients.

Keywords: Lipid, statin therapy; Turkey.

How to cite this article
Volkan Doğan, Özcan Başaran, Bülent Özlek, Oğuzhan Çelik, Eda Özlek, Kadir Uğur Mert, İbrahim Rencüzoğulları, Gurbet Özge Mert, Marwa Mouline Doğan, Murat Biteker, Meral Kayıkçıoğlu. Rationale, design, and methodology of the Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia. Turk Kardiyol Dern Ars. 2018; 46(1): 47-53

Corresponding Author: Volkan Doğan, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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