Archives of the Turkish Society of Cardiology
Parameters of ventricular repolarization in patients with autoimmune hepatitis [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2017; 45(4): 333-338 | DOI: 10.5543/tkda.2017.57870

Parameters of ventricular repolarization in patients with autoimmune hepatitis

Burak Açar1, Mahmut Yüksel2, Çağrı Yayla1, Özgür Kırbaş1, Sefa Ünal1, Ahmet Göktuğ Ertem1, Koray Demirtaş1, Mustafa Kaplan2, Meral Akdoğan2, Sabite Kaçar2, Ertuğrul Kayaçetin2, Sinan Aydoğdu1
1Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, Turkey
2Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.


OBJECTIVE
Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults. It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in the absence of known etiology. Ventricular repolarization has been evaluated using T wave and QT interval measurements in patients with hepatic cirrhosis. Ventricular repolarization may be defined using QT interval, QT dispersion, and T wave measurements. Recently, it has been demonstrated that peak and end of the T wave (Tp-e) interval, Tp-e/QT, and Tp-e/corrected QT interval (QTc) ratios can be novel indicators for prediction of ventricular arrhythmias and mortality. In this study, an investigation of ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with AIH was performed.

METHODS
Total of 31 patients with AIH and 31 controls were enrolled in the present study. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured on 12-lead electrocardiogram.

RESULTS
QT interval (378.9±41.4 vs. 350.0±22.7; p=0.001), QTc interval (396.8±46.7 vs. 367.3±34.9; p=0.039), Tp-e interval (68.2±12.3 vs. 42.5±6.8; p<0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.12±0.01; p<0.001) and Tp-e/QTc ratio (0.17±0.02 vs. 0.11±0.01; p<0.001) were significantly higher in patients with AIH than control patients.

CONCLUSION
The results of the present study indicated that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were greater in patients with AIH.

Keywords: Autoimmune hepatitis, Tp-e interval, Tp-e/QT ratio

Burak Açar, Mahmut Yüksel, Çağrı Yayla, Özgür Kırbaş, Sefa Ünal, Ahmet Göktuğ Ertem, Koray Demirtaş, Mustafa Kaplan, Meral Akdoğan, Sabite Kaçar, Ertuğrul Kayaçetin, Sinan Aydoğdu. Parameters of ventricular repolarization in patients with autoimmune hepatitis. Turk Kardiyol Dern Ars. 2017; 45(4): 333-338

Corresponding Author: Çağrı Yayla, Türkiye
© copyright 2017 Archives of the Turkish Society of Cardiology
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