ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Diagonal earlobe crease associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(6): 474-480 | DOI: 10.5543/tkda.2016.37806

Diagonal earlobe crease associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease

Murat Ziyrek1, Sinan Sahin2, Emrah Ozdemir3, Zeydin Acar2, Serkan Kahraman1
1Silivri State Hospital, Department Of Cardiology, İstanbul
2Kanuni Education And Research Hospital Department Of Cardiology, Trabzon
3Yeniyuzyıl University School Of Medicine Gaziosmanpasa Education And Research Hospital Departmet Of Cardiology


OBJECTIVE
Atherosclerotic coronary artery disease is a leading cause of death, worldwide. Diagonal earlobe crease (DELC) has been suggested as a simple, noninvasive marker of cardiovascular disease. Although epicardial adipose tissue (EAT) thickness and carotid intima media thickness (CIMT) are closely related to atherosclerosis, the relation between EAT, CIMT, and DELC had yet to be studied. The present objective was to analyze this association.

METHODS
Subjects were apparently healthy individuals referred to the cardiology outpatient clinic. A total of 65 subjects with DELC and 65 age- and sex-matched controls without DELC were enrolled. EAT thickness and CIMT were measured and analyzed.

RESULTS
Epicardial adipose tissue thickness was significantly higher in the DELC group (0.57±0.12 vs. 0.35±0.05; p<0.0001). CIMT was also significantly higher in DELC group (0.85±0.16 vs. 0.60±0.15; p<0.0001). Correlation analysis showed that CIMT was significantly correlated with EAT thickness (r: 0.594; p<0.0001). Linear regression analysis showed that presence of DELC was independently associated with CIMT and EAT thickness.

CONCLUSION
A significant and independent association between the presence of DELC and increased CIMT and EAT thickness was presently determined, for the first time, in subjects free of clinical cardiovascular disease.

Keywords: Atherosclerosis, diagonal ear lobe crease, epicardial adipose tissue, intima media thickness.

How to cite this article
Murat Ziyrek, Sinan Sahin, Emrah Ozdemir, Zeydin Acar, Serkan Kahraman. Diagonal earlobe crease associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease. Turk Kardiyol Dern Ars. 2016; 44(6): 474-480

Corresponding Author: Murat Ziyrek, Türkiye
Manuscript Language: English


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