ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(3): 265-273 | DOI: 10.5543/tkda.2014.36089

Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats

Ayça Bilginoğlu1, Duygu Aydın2, Şeyma Özsoy3, Hatice Aygün3
1Department of Biophysics, Yıldırım Beyazıt University Faculty of Medicine, Ankara
2Department of Physiology, Turgut Özal University Faculty of Medicine, Ankara
3Department of Physiology, Gaziosmanpaşa University Faculty of Medicine, Tokat


OBJECTIVES
Adriamycin is one of the most widely used anticancer drugs. The major limiting factor of using this drug is the development of cardiotoxicity. However, melatonin (N-acetyl- 5-methoxytryptamine) is a ubiquitous molecule as a good antioxidant that may protect the heart. We investigated whether or not pretreatment with melatonin can attenuate adriamycininduced cardiotoxicity.

STUDY DESIGN
All procedures and experiments were approved by the Animal Ethics Committee of Gazi Osman Paşa University (2012-HADYEK-022). Adult male Wistar-Albino rats were randomly divided into four groups, namely control (CON, n=7), melatonin (MEL, n=7), adriamycin (ADR, n=7), and adriamycin+melatonin (ADR+MEL, n=7) groups. Cardiotoxicity in rats was induced by adriamycin injection (cumulative dose: 18 mg/kg, intraperitoneal [i.p.]) at an interval of 24 hours (h) on the 5th, 6th and 7th days. Rats receiving melatonin treatment in the adriamycin group received melatonin (10 mg/kg/day, i.p.) for 7 days and were injected with adriamycin (18 mg/kg, i.p.) on 5th, 6th and 7th days. On the 8th day, gravimetric, electrocardiography (ECG) and biochemical parameters were assessed.

RESULTS
Adriamycin induction caused changes in the ECG pattern, including ST-segment elevation and decreased Ramplitude, increase in the serum levels of cardiac injury markers (creatine kinase [CK], CK-MB, aspartate transaminase, and lactate dehydrogenase), decrease in the antioxidant enzymes activity (superoxide dismutase, glutathione peroxidase), elevated lipid peroxidation (malondialdehyde), and altered lipid profile in the serum. Melatonin treatment prevented all the parameters of adriamycin-induced cardiotoxicity in rats.

CONCLUSION
Melatonin has a protective effect on the heart against adriamycin-induced cardiotoxicity in rats.

Keywords: Adriamycin, antioxidants; cardiovascular diseases/prevention & control; coronary disease; disease models, animal; melatonin; rats, Wistar.

How to cite this article
Ayça Bilginoğlu, Duygu Aydın, Şeyma Özsoy, Hatice Aygün. Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats. Turk Kardiyol Dern Ars. 2014; 42(3): 265-273

Corresponding Author: Ayça Bilginoğlu, Türkiye
Manuscript Language: English


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