ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2017; 45(1): 9-15 | DOI: 10.5543/tkda.2016.17971

Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale

Nermin Bayar1, Selçuk Küçükseymen1, Zehra Erkal1, Ramazan Güven2, Erkan Köklü1, Çağın Mustafa Üreyen3, Şakir Arslan1
1Antalya Education and Research Hospital, Cardiology department, Antalya, Turkey
2Bitlis State Hospital, Emergency Medicine Department, Antalya, Turkey
3Sakarya University Education and Research Hospital, Cardiology department, Sakarya, Turkey


OBJECTIVE
Patent foramen ovale (PFO) is commonly encountered in patients with cryptogenic stroke. Mean platelet volume (MPV), an indicator of platelet reactivity, has been reported in recent trials to be higher in patients with PFO than in normal population. The aim of this study was to investigate whether there is a difference in MPV between patients with PFO and stroke or transient ischemic attack (TIA) and that of patients with asymptomatic PFO.

METHODS
Patients with PFO who were younger than 55 years of age were enrolled in this retrospective study. Hemogram parameters of patients with ischemic stroke or TIA (symptomatic group) were obtained during hospitalization once they had stable clinical status.

RESULTS
Total of 108 patients, 51 of whom were symptomatic, were included in the study. MPV was determined to be higher in symptomatic group compared with asymptomatic group (median 10.0 fl [25th-75th percentile: 9.0–11.0] vs median 8.56 fl [25th-75th percentile: 8.0–9.0], respectively; p<0.001,. Cut-off point of 9.0 fl for MPV had 70% sensitivity and 86% specificity in predicting symptomatic PFO patients.


CONCLUSION
MPV is higher in symptomatic than in asymptomatic PFO patients. This finding may be a subsidiary risk factor to identify patients with PFO and high risk of cardioembolic stroke.

Keywords: Mean platelet volume, patent foramen ovale, stroke.

How to cite this article
Nermin Bayar, Selçuk Küçükseymen, Zehra Erkal, Ramazan Güven, Erkan Köklü, Çağın Mustafa Üreyen, Şakir Arslan. Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale. Turk Kardiyol Dern Ars. 2017; 45(1): 9-15

Corresponding Author: Nermin Bayar, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
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