Archives of the Turkish Society of Cardiology
The relationship between serum lipid parameters and renal frame count in hypertensive patients with normal renal functions [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2017; 45(4): 348-354 | DOI: 10.5543/tkda.2017.05248

The relationship between serum lipid parameters and renal frame count in hypertensive patients with normal renal functions

Emrah Ipek1, Mustafa Yolcu2, Erkan Yıldırım1
1Department of Cardiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
2Department of Cardiology, Arel University Faculty of Medicine, İstanbul, Turkey


OBJECTIVE
Atherosclerosis can contribute to renovascular disease, and high cholesterol level is an independent risk factor for disease progression. Renal frame count (RFC) is an objective angiographic method of measuring macrovascular blood flow in the main renal artery and its segmental branches. The aim of the present study was to demonstrate relationship between serum lipid parameters and RFC.

METHODS
In this cross-sectional study, 116 hypertensive patients were allocated into 2 groups according to serum low-density lipoprotein (LDL) levels. Group 1 comprised 60 patients with LDL <130 mg/dL and Group 2 consisted of 56 individuals with LDL ≥130 mg/dL. The patients were also divided into 2 groups according to total cholesterol (TC) levels (52 patients in group with TC <200 mg/dL and 64 patients in group with TC ≥200 mg/dL).

RESULTS
Group 2 had higher mean RFC than Group 1 (p<0.001). RFC of both kidneys in Group 2 was significantly higher than results in Group 1 (p<0.001 and p=0.023, respectively). We found similar significant results in comparison of TC-based patient groups. RFC had positive correlation with smoking, TC, and LDL (r=0.326, p=0.035; r=0.393, p=0.010; and r=0.386, p=0.012, respectively). In multivariate linear regression analysis, LDL, TC, smoking, and creatinine clearance were independent predictors of RFC.

CONCLUSION
In conclusion, in hypertensive patients with normal renal function, LDL, TC, and smoking may be predictors of RFC and aggressive risk factor modification may help to reduce the risk of renal failure.

Keywords: Cholesterol, hypertension, LDL, renal frame count, smoking.

Emrah Ipek, Mustafa Yolcu, Erkan Yıldırım. The relationship between serum lipid parameters and renal frame count in hypertensive patients with normal renal functions. Turk Kardiyol Dern Ars. 2017; 45(4): 348-354

Corresponding Author: Emrah Ipek, Türkiye
© copyright 2017 Archives of the Turkish Society of Cardiology
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