Comparison of the Effects of Captopril and Valsartan on Heart Rate Variability in Healthy Men [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2003; 31(6): 338-346

Comparison of the Effects of Captopril and Valsartan on Heart Rate Variability in Healthy Men

Dayimi Kaya1, Ali Metin Esen1, İrfan Barutçu1, Ataç Çelik1, Celal Kilit1, Ersel Onra1


OBJECTIVE
Angiotensin II is well known to have several effects on cardiovascular autonomic functions. However, there is no data regarding the head to head comparison of the effect of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers, the major drugs to inhibit angiotensin II, on heart rate variability (HRV). The aim of this study is to compare the effects of a single dose ACE inhibitor (captopril: 25 mg) and an angiotensin receptor blocker (valsartan: 80 mg) on HRV parameters. Material and
METHODS
The effects of a single oral dose of captopril, valsartan and placebo on 9 healthy male individuals (mean age 28±2 years) were studied in a double blind crossover placebo controlled study on three occasions. Frequency and time domain parameters of HRV were measured during supine position and during handgrip exercise before and after taking each agent.
RESULTS
Baseline blood pressure values, heart rates and HRV parameters were not found statistically different on each occasion. With captopril but not valsartan administration, heart rate at supine position decreased significantly in comparison with the baseline values without a change in HRV parameters (865±33 vs. 917±39, p=0.038). When compared to placebo during handgrip exercise, captopril caused a significant increase in the standard deviation of R-R interval (SDNN), which is a global HRV marker (50±5 ms vs. 58±5 ms, p=0.035, respectively).
CONCLUSION
Captopril not only increases vagal tone at rest without altering vagal modulation but also increases SDNN during handgrip exercise. However these effects are not observed with valsartan.

Keywords: Captopril, heart rate variability, valsartan

How to cite this article
Dayimi Kaya, Ali Metin Esen, İrfan Barutçu, Ataç Çelik, Celal Kilit, Ersel Onra. Comparison of the Effects of Captopril and Valsartan on Heart Rate Variability in Healthy Men. Turk Kardiyol Dern Ars. 2003; 31(6): 338-346
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