Effects of Prior Beta-Blocker Therapy on CK-MB Rise After Successful Percutaneous Coronary Interventions [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2003; 31(9): 473-481

Effects of Prior Beta-Blocker Therapy on CK-MB Rise After Successful Percutaneous Coronary Interventions

İlyas Atar1, Mehmet Emin Korkmaz1, İnci Aslı Atar1, Öykü Gülmez1, Hüseyin Bozbaş1, Alparslan Küçük1, Bülent Özin1, Aylin Yıldırır1, Egemen Tayfun1, Haldun Müderrisoğlu1

Effects of Prior Beta-Blocker Therapy on CK-MB Rise After Successful Percutaneous Coronary Interventions Creatine kinase (CK)-MB isoenzymes are elevated after 6% to 40% of successful percutaneous coronary interventions (PCI). Except some nonrandomized studies, there are no data regarding the effects of beta-blocker (BB) usage on CK-MB after PCI. We, thus planned to investigate the impact regarding BB usage on CK-MB in patients who underwent successful PCI. We enrolled 300 patients with coronary artery disease in whom PCI was selected as the revascularization modality. Patients were randomized to either BB or control groups at least 1 week before the planned PCI. Patients recieved 50 or 100 mg of metoprolol depending on their blood pressure. Blood samples for cardiac enzymes were obtained immediately, and 6th, 24th and 36th hours after the procedure. Mean age of the study group was 49.4 ± 9.7, and 73.3% of the patients (220/300) were male. Baseline clinical characteristics, medications and laboratory parameters of both groups were similar. CK-MB levels before PCI were normal in all patients. There were no differences between the in-hospital complications of the 2 groups. We did not observe a significant difference in the percentage of patients who had CK-MB elevations between the 2 groups after PCI [BB 18 % (27 patients), control 20 % (30 patients) (p > 0.05)]. The mean CK-MB levels immediately after the PCI and at the 6th, 24th and 36th hours were also similar. In the first randomized, prospective study conducted to evaluate the effect of BB usage on CK-MB levels after PCI, prior BB therapy seemed to have no cardioprotective effect in limiting CK-MB rise after PCI.

Keywords: ß-blocker, CK-MB, percutaneous coronary interventions

How to cite this article
İlyas Atar, Mehmet Emin Korkmaz, İnci Aslı Atar, Öykü Gülmez, Hüseyin Bozbaş, Alparslan Küçük, Bülent Özin, Aylin Yıldırır, Egemen Tayfun, Haldun Müderrisoğlu. Effects of Prior Beta-Blocker Therapy on CK-MB Rise After Successful Percutaneous Coronary Interventions. Turk Kardiyol Dern Ars. 2003; 31(9): 473-481
© Copyright 2019 Archives of the Turkish Society of Cardiology
LookUs & Online Makale