ISSN 1016-5169 | E-ISSN 1308-4488
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Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2013; 41(7): 604-609 | DOI: 10.5543/tkda.2013.93385

Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension

Abdulkadir Yıldız, Hasan Kaya, Faruk Ertas, Mustafa Oylumlu, Mehmet Zihni Bilik, Murat Yüksel, Nihat Polat, Mehmet Ata Akil, Zuhal Atılgan, Mehmet Sıddık Ülgen
Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakir, Turkey


OBJECTIVES
Pulmonary hypertension (PH) is composed of a heterogeneous group of disorders marked by increased pulmonary artery resistance leading to right heart failure, with high mortality. Evidence is increasing to propose that inflammation plays a significant role in the pathophysiological mechanism. Increased prevalence of PH in patients with systemic inflammatory diseases is already known. Herein, we sought to evaluate the association between neutrophil to lymphocyte ratio (N/L ratio) and pulmonary arterial hypertension (PAH).

STUDY DESIGN
Twenty-five patients with PAH and 25 controls were evaluated. Baseline clinical and echocardiographic variables were obtained. Complete blood counts in all patients and controls were reviewed retrospectively.

RESULTS
The N/L ratio was higher in patients with PAH compared to healthy volunteers (p=0.05). A cut-off value of 1.65 for N/L ratio predicted the presence of PAH with 72% sensitivity and 69% specificity. After multivariate analysis, only N/L ratio remained a significant predictor of PAH.

CONCLUSION
We showed for the first time that N/L ratio was significantly increased in patients with PAH compared to controls.

Keywords: Biological markers, heart failure, hypertension, pulmonary; N/L oranı; pulmonary artery; inflammation.

How to cite this article
Abdulkadir Yıldız, Hasan Kaya, Faruk Ertas, Mustafa Oylumlu, Mehmet Zihni Bilik, Murat Yüksel, Nihat Polat, Mehmet Ata Akil, Zuhal Atılgan, Mehmet Sıddık Ülgen. Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. Turk Kardiyol Dern Ars. 2013; 41(7): 604-609

Corresponding Author: Abdulkadir Yıldız, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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