The relationship between serum total testosterone and 24-hour urinary sodium excretion in never-treated stage 1 essential hypertensive patients [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(4): 316-322 | DOI: 10.5543/tkda.2012.81557

The relationship between serum total testosterone and 24-hour urinary sodium excretion in never-treated stage 1 essential hypertensive patients

Barış Afşar1, Mahmut Ay2, Rukuye Burucu3, Alper Kırkpantur4
1Department of Nephrology, Konya Numune State Hospital, Konya, Turkey
2Department of Biochemistry, Konya Numune State Hospital, Konya, Turkey
3Department of Nursery, Konya Numune State Hospital, Konya, Turkey
4RFM Dialysis Center, Ankara, Turkey


OBJECTIVES
To study the relationship between serum total testosterone (TT) and 24-hour urinary sodium excretion in newly diagnosed stage 1 essential hypertensive patients with normal renal function.

STUDY DESIGN
In total, 80 never-treated stage 1 hypertensive patients were included. All patients provided medical history and underwent physical examination, blood pressure measurement, 12-lead electrocardiography, routine urine analysis, biochemical analysis, 24-hour urine collection to measure urinary sodium and protein excretion, and creatinine clearance calculation.

RESULTS
Pearson correlation analysis revealed that logarithmically converted 24-hour urinary sodium excretion was correlated with age (r=-0.399, p<0.0001), body mass index, (r=0.304, p=0.006), systolic blood pressure (r=0.394, p<0.0001), serum potassium (r=0.233, p=0.037), creatinine clearance (r=0.600, p<0.0001), and logarithmically converted serum TT (r=-0.272, p=0.015). Stepwise linear regression analysis revealed that age (p<0.0001), creatinine clearance (p=0.015), systolic blood pressure (p<0.0001), potassium (p=0.021), and serum TT (p=0.002) were independently related to logarithmically converted 24-hour sodium excretion.

CONCLUSION
We demonstrated that serum TT levels were independently related to 24-hour urinary sodium amount.

Keywords: Blood pressure, body mass index, hypertension, hypertensive patients; renal function; sodium chloride/adverse effects; sodium/urine; total testosterone

How to cite this article
Barış Afşar, Mahmut Ay, Rukuye Burucu, Alper Kırkpantur. The relationship between serum total testosterone and 24-hour urinary sodium excretion in never-treated stage 1 essential hypertensive patients. Turk Kardiyol Dern Ars. 2012; 40(4): 316-322

Corresponding Author: Barış Afşar, Türkiye
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