Turk Kardiyol Dern Ars. Ahead of Print: TKDA-78379 | DOI: 10.5543/tkda.2019.78379
Peripheral polyneuropathy in patients receiving long-term statin therapy
ibrahim halil özdemir1
, Ozge Copkiran2
, Hakan TIKIZ3
, canan Tıkız41
Department Of Cardiology, Nizip State Hospital, Gaziantep, Turkey2
Department Of Cardiology, Menemen State Hospital, İzmir, Turkey3
Department Of Cardiology, Celal Bayar University, Manisa, Turkey4
Departmant Of Physical Therapy And Rehabilitation, Celal Bayar University, Manisa, Turkey
OBJECTIVE Peripheral neuropathy is an important side effect of statins.We investigated the incidence of peripheral neuropathy with atorvastatin or rosuvastatin prescribed for hypercholesterolemia and its relationship with the dose and duration of the treatment.
METHODS 50 patients on statins and 50 healthy controls matched for age and gender who never had statins were included in the study.The polyneuropathy was assessed by neurological examination and electroneuromyography(ENMG).
RESULTS While no polyneuropathy was detected in the control group,33(66%) of the patients in statin group(p<0.01) had polyneuropathy.There was no significant difference between statin groups on neurological examination,the ENMG findings and incidence of polyneuropathy(respectively,p=0.288 and p=0.720).Neuropathy was observed on neurological examination within first year(rosuvastatin %50,atorvastatin %18).The severity of the polyneuropathy increased with the duration of the treatment in the atorvastatin group(p=0.030).
CONCLUSION Our study revealed an increased risk of peripheral neuropathy with long-term statin use(over 1 year).Electrodiagnostic changes are detected in motor and sensory nerves in nerve conduction studies in patients on long term statin treatment compared to the control group individuals.The assessment of neurologic symptoms like tingling, numbness, pain,and tremor in the hands and feet and unsteadiness during walking associated with peripheral neuropathy may be useful in the follow up of the patients on long term statin treatment. Early detection of peripheral neuropathy may prevent permanent nerve damage by changing hypercholesterolemia treatment.
Statin, peripheral neuropathy, atorvastatin, rosuvastatin
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Corresponding Author: ibrahim halil özdemir, Türkiye