Turk Kardiyol Dern Ars. 2015; 43(2): 157-165 | DOI: 10.5543/tkda.2015.76281
The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure
, Abdulkadir Yildiz, Mehmet Zihni Bilik, Mesut Aydın, Halit Acet, Hasan Kaya, Muhammet Demir, Mehmet Ali Isik, Sait Alan, Nizamettin Toprak
Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakir, Turkey
OBJECTIVES In patients with heart failure, a variety of hemogram parameters are known to be of prognostic significance. This study aimed to investigate which of these parameters is/ are useful in predicting one-year all-cause mortality in patients with acute decompensated heart failure (ADHF).
STUDY DESIGN Patients who were hospitalized between September 2012-March 2013 in our hospital with systolic-ADHF with ejection fraction ≤40%, symptoms, and findings of congestion were enrolled retrospectively in the study. The study population was divided into two groups based on one-year-mortality.
RESULTS 119 patients with ADHF (mean-age 67±14 years; 55% male) were enrolled in the study. One-year-mortality occurred in 29% of patients. Hemoglobin levels, platelet, basophil and lymphocyte counts were significantly lower, while red-cell distribution width (RDW) was found to be significantly higher in the one-year-mortality group. Neutrophil, monocyte, and eosinophil counts were similar in the two groups. Furthermore, lower estimated glomerular-filtration-rate (eGFR) and unused angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) were associated with mortality. Age, presence of hypertension, right-ventricular diameter, eGFR, ACE/ARB treatment, hemoglobin levels, RDW and platelet, leukocyte, lymphocyte, basophil, neutrophil, monocyte, and eosinophil-counts were found to have prognostic significance in univariate analysis. In multivariate analysis, decreased platelet, lymphocyte-counts and hemoglobin level on admission and unused ACE/ARB treatment at discharge (p<0.05) were found to be independent factors predicting one-year-mortality.
CONCLUSION Among hematological indices; hemoglobin level, platelet and lymphocyte counts are readily available, useful and inexpensive markers for the prediction of one-year allcause mortality in ADHF patients.
Blood platelets, heart failure; hemoglobins; mortality; predictive value of tests
How to cite this article
Nihat Polat, Abdulkadir Yildiz, Mehmet Zihni Bilik, Mesut Aydın, Halit Acet, Hasan Kaya, Muhammet Demir, Mehmet Ali Isik, Sait Alan, Nizamettin Toprak. The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Turk Kardiyol Dern Ars. 2015; 43(2): 157-165
Corresponding Author: Nihat Polat, Türkiye