Turk Kardiyol Dern Ars. 2011; 39(5): 371-377 | DOI: 10.5543/tkda.2011.01382
The relationship between paraoxonase-1 activity and coronary artery disease in patients with metabolic syndrome
Adnan Burak Akçay1
, Ahmet Çamsarı2
, Türkay Özcan2
, Dilek Çiçek2
, Necdet Akkuş2
, Sabri Seyis2
, Burak Çimen3
, Barış Çelebi2
, Oben Döven2
, Gökhan Cin21
Department of Cardiology, School of Medicine, Mustafa Kemal University, Antioch, Turkey2
Department of Cardiology, School of Medicine, Mersin University, Mersin, Turkey3
Department of Biochemistry, School of Medicine, Mersin University, Mersin, Turkey.
OBJECTIVES We investigated the correlation of serum paraoxonase-1 (PON-1) activity with coronary artery disease (CAD) in patients with metabolic syndrome (MetS).
STUDY DESIGN The study included 21 patients (mean age 55±9 years) with MetS, stable angina pectoris, and angiographically shown CAD, 24 patients (mean age 51±10 years) with MetS and angiographically normal coroner arteries, and 28 healthy controls (mean age 49±12 years). Demographic and clinical characteristics, insulin levels, homeostasis model assessment of insulin resistance index, and PON-1 activity were assessed in all the groups. Severity of CAD was assessed using the Gensini score.
RESULTS Paraoxonase-1 activity was significantly lower in patients with MetS compared to the control group (p=0.02). The two MetS groups with and without CAD exhibited similar characteristics in all the parameters including PON-1 activity (p>0.05). Univariate correlation analysis performed in MetS-CAD patients showed a significant negative correlation between the Gensini score and PON-1 activity (r=-0.48, p=0.02). The overall PON-1 activity of all the subjects showed no correlation with the parameters examined.
CONCLUSION Decreased PON-1 activity in patients with MetS compared to the control group suggests increased oxidative stress in MetS. Detection of similar PON-1 activity levels in MetS groups with and without CAD suggests that disturbance of oxidative-antioxidative balance occurs before the development of CAD. The negative correlation between the Gensini score and PON-1 activity implies that decreased PON-1 activity may be one of the etiologic causes of atherosclerotic progress in MetS.
Angina, unstable, antioxidants, aryldialkylphosphatase/ blood; coronary artery disease; metabolic syndrome X
How to cite this article
Adnan Burak Akçay, Ahmet Çamsarı, Türkay Özcan, Dilek Çiçek, Necdet Akkuş, Sabri Seyis, Burak Çimen, Barış Çelebi, Oben Döven, Gökhan Cin. The relationship between paraoxonase-1 activity and coronary artery disease in patients with metabolic syndrome. Turk Kardiyol Dern Ars. 2011; 39(5): 371-377
Corresponding Author: Adnan Burak Akçay, Türkiye