Effect of Glucose Insulin Potassium Infusion on Myocardial Injury and Endothelin-1 Levels in Chronic Ischemic Heart Failure [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2004; 32(2): 99-106

Effect of Glucose Insulin Potassium Infusion on Myocardial Injury and Endothelin-1 Levels in Chronic Ischemic Heart Failure

Y.Mustafa YAZICI1, Sabri DEMİRCAN1, Emre AKSAKAL1, Korhan SOYLU1, Mahmut ŞAHİN1, Olcay SAĞKAN1

In this study, the effects of long term glucose insulin potassium (GIK) infusion on myocardial injury and endothelin-1 levels in patients with chronic ischemic heart failure were assessed. 56 patients with NYHA functional class III-IV chronic ischemic heart failure were included who had past history of myocardial infarction (> 6 months) and obstructive coronary artery disease determined by angiography. In addition to the standard therapy administered, GIK infusion (30% 500 cc glucose + 300 U insulin + 60 mEq KCl) for 8 hours every day during 5 days was given for the randomly selected 35 patients (Group A). Those with standard treatment (21 patients, Group B) served as a control group. Echocardiographic examination as well as measurement of ET-1 and cardiac troponin-I (cTn-I) levels from venous blood samples were carried out before and after therapy in both groups. There was no significant difference in blood glucose and K+ levels during follow-up and GIK infusion. Arrhythmia and hemodynamic change were not observed. Plasma ET-1 levels were similar in both groups before treatment (Group A 3.31±0.42 pg/ml and Group B 3.36±0.53 pg/ml, p>0.05). A significant decrease in plasma ET-1 levels of both groups was noted after treatment compared to pretreatment levels (Group A 2.02±0.33 pg/ml, p<0.0001 and Group B 3.12±0.61 pg/ml, p<0.01). Decrease in ET-1 levels were more significant in the GIK group (p<0.0001). Left ventricular ejection fractions after treatment revealed a significant increase in the GIK group (p<0.001). The decrease in cTn-I levels after treatment was also significantly more prominent in the GIK group (p<0.001). We concluded that a positive effect existed of long-term GIK infusion on myocardial injury and ET-1 levels, accepted as one of hemodynamic parameters of heart failure. Long-term GIK infusion may have positive contribution to clinical progression of patients with chronic ischemic heart failure, in addition to standard treatment. (Türk Kardiyol Dern Arş 2004; 32: 99-106)

Keywords: Chronic heart failure, endothelin-1, glucose-insulin-potassium infusion, myocardial injury

How to cite this article
Y.Mustafa YAZICI, Sabri DEMİRCAN, Emre AKSAKAL, Korhan SOYLU, Mahmut ŞAHİN, Olcay SAĞKAN. Effect of Glucose Insulin Potassium Infusion on Myocardial Injury and Endothelin-1 Levels in Chronic Ischemic Heart Failure. Turk Kardiyol Dern Ars. 2004; 32(2): 99-106
© Copyright 2019 Archives of the Turkish Society of Cardiology
LookUs & Online Makale