ISSN 1016-5169 | E-ISSN 1308-4488
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Evaluation of arterial stiffness and subclinical atherosclerosis in patients with Behçet’s disease without cardiovascular involvement [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(7): 575-581 | DOI: 10.5543/tkda.2016.06944

Evaluation of arterial stiffness and subclinical atherosclerosis in patients with Behçet’s disease without cardiovascular involvement

Alp Yıldırım1, Mustafa Serkan Karakaş2, Ali Yaşar Kılınç2, Refik Emre Altekin2, Ali Selim Yalçınkaya2
1Kars State Hospital, Department Of Cardiology. Kars, Turkey
2Akdeniz University Medical Faculty, Department Of Cardiology. Antalya, Turkey


OBJECTIVE
This study was conducted to evaluate arterial structure and function with assessment of pulse wave velocity (PWV) and carotid intima-media thickness (CIMT) in patients with Behçet’s disease (BD).


METHODS
Thirty patients (13 female, 17 male) with BD and 30 age, sex-matched healthy controls (12 female, 18 male) with no known cardiovascular disease were enrolled in this study. Carotid-femoral PWV and CIMT were measured.


RESULTS
PWV was higher in BD patients compared with control group (6.35±1.05 vs. 5.75±0.83, respectively; p=0.017). There was no significant difference in maximum CIMT (0.751±0.077 mm vs. 0.735±0.079 mm, respectively; p=0.435), or mean CIMT (0.643±0.070 mm vs. 0.629±0.069, respectively; p=0.452). Maximum CIMT, mean CIMT, and PWV were positively correlated with duration of disease (r=0.410, p=0.025; r=0.404, p=0.027; and r=0.362, p=0.049, respectively).


CONCLUSION
Findings suggest that endothelial function is impaired in cases of BD before visible structural changes to arterial wall. PWV is more useful measurement than CIMT in determination of vascular damage in BD, especially in early stage of disease duration.

Keywords: Atherosclerosis, Behçet’s disease, carotid intima-media thickness, pulse wave velocity.

How to cite this article
Alp Yıldırım, Mustafa Serkan Karakaş, Ali Yaşar Kılınç, Refik Emre Altekin, Ali Selim Yalçınkaya. Evaluation of arterial stiffness and subclinical atherosclerosis in patients with Behçet’s disease without cardiovascular involvement. Turk Kardiyol Dern Ars. 2016; 44(7): 575-581

Corresponding Author: Mustafa Serkan Karakaş, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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